| 食管癌中p27表达及其临床意义 |
| |
| 引用本文： | 王忠民,唐怀好,李汉臣,张超纪,杨红伟,乔刚,张杰. 食管癌中p27表达及其临床意义[J]. 陕西医学杂志, 2005, 34(1): 23-26 |
| |
| 作者姓名： | 王忠民 唐怀好 李汉臣 张超纪 杨红伟 乔刚 张杰 |
| |
| 作者单位： | 新乡医学院第一附属医院胸外科,卫辉,453100 |
| |
| 摘 要： | 目的 :探讨食管癌组织中 p2 7表达及其临床意义。方法 :采用免疫组化染色( SP)法 ,对 1 1 0例食管癌及 30例癌旁组织 p2 7进行检测 ,并进行统计学分析。结果 :1 1 0例食管癌组织中 ,5 1例 p2 7表达呈阳性 ,阳性率达 46.4% ,癌旁组织中 2 2例呈阳性 ,阳性率 73.3% ,二者之间有显著性差异 ( P<0 .0 5 ) ,p2 7表达与肿块大小、淋巴结转移、病理分级和预后显著相关 ( P<0 .0 5 )。结论 :p2 7表达可作为食管癌诊断指标之一 ,与其生存预后有关。
|
| 关 键 词： | 食管肿瘤/诊断 细胞周期蛋白质类/代谢 |
Clinical significance of p27 expression in esophageal carcinomatous tissue |
| |
| Affiliation: | Weihui 453100 |
| |
| Abstract: | Objective:To discuss the expression of p27 in esophageal carcinomatous tissue and it's clinical signidficance.Methods:110 specimens of esophageal carcinomatous tissue and 30 specimens of surrounding tissue of carcinoma were tested by immunohistochemical staining (SP) method.The data was statistically analysed. Results:The positive rates of p27 expression in carcinomatous tissue and surrounding carcinomatous tissue were 46.4%(51/110) and 73.3%(22/30) respectively.The diffrence was significant(P<0.05).The expression of p27 was significantly related to the size of tumour,lymphatic transmission,pathologic levels and prognosis(P<0.05).Conclusion:The expression of p27 may be one of the factors in esophageal carcinoma diagnosis.It's related to the survival and prognosis. |
| |
| Keywords: | Esophageal neoplasms/diagnosis Cell cycle proteins/metabolism |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
