| 中药材中198种农药残留测定样品前处理平台的建立 |
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| 引用本文： | 王莹,金红宇,孙磊,马双成. 中药材中198种农药残留测定样品前处理平台的建立[J]. 药物分析杂志, 2011, 0(12) |
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| 作者姓名： | 王莹 金红宇 孙磊 马双成 |
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| 作者单位： | 中国食品药品检定研究院; |
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| 基金项目： | 国家十一五“重大新药创制”,课题名称“中药中有害残留物检测技术标准平台”(编号2009ZX09306) |
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| 摘 要： | 目的:建立气相色谱-质谱测定中药材中198种农药残留的分析方法。方法:用丙酮进行提取,采用凝胶渗透色谱(GPC)或GPC与固相萃取(SPE)结合净化的方法,并优化了GPC与SPE方法。最终根据药用部位及基质成分对中药材进行分类,分别采取不同的前处理方法。结果:使用此方法对山药、黄芪、金银花、陈皮等中药材进行了考察,回收率大多处于70%～110%之间,RSD为2.7%～13.6%,符合痕量分析要求。结论:此方法灵敏度高,准确,可靠,为中药材中的农药多残留测定提供了一种准确实用的分析方法。
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| 关 键 词： | 农药多残留 凝胶渗透色谱 固相萃取 中药材 气相色谱-质谱联用 |
Research of pretreatment platform for simultaneous determination of 198 pesticides in traditional Chinese medicine |
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| WANG Ying,JIN Hong-yu,SUN Lei,MA Shuang-cheng. Research of pretreatment platform for simultaneous determination of 198 pesticides in traditional Chinese medicine[J]. Chinese Journal of Pharmaceutical Analysis, 2011, 0(12) |
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| Authors: | WANG Ying JIN Hong-yu SUN Lei MA Shuang-cheng |
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| Affiliation: | WANG Ying,JIN Hong-yu,SUN Lei,MA Shuang-cheng (National Institutes for Food and Drug Control,Beijing 100050,China) |
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| Abstract: | Objective:To establish a GC-MS method for simultaneous determination of 198 pesticides in traditional Chinese medicine.Methods:The samples were extracted with acetone,and clean-up by gel permeation chromatography(GPC) or the combination of GPC with solid-phase extraction(SPE).The pretreatment of method was optimized.And the different clean-up methods for Chinese herbs according to the medicament portions and matrix were used.Results:Four Chinese herbs(including Rhizome Dioscoreae,Radix Astragali,Flos Lonice... |
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| Keywords: | multiresidual pesticides gel permeation chromatography solid-phase extraction traditional Chinese medicine gas chromatography-mass spectrometry |
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