| 超高效液相色谱-串联质谱法测定中草药中氨基甲酸酯类农药残留量 |
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| 引用本文： | 李娜,刘磊,邵辉,李辉,张玉婷,宋海菲,郭永泽. 超高效液相色谱-串联质谱法测定中草药中氨基甲酸酯类农药残留量[J]. 药物分析杂志, 2011, 0(12) |
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| 作者姓名： | 李娜 刘磊 邵辉 李辉 张玉婷 宋海菲 郭永泽 |
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| 作者单位： | 天津市农业科学院中心实验室; |
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| 基金项目： | 国家重大专项子课题(2009ZX09502-027-2)项目资助 |
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| 摘 要： | 目的:结合固相萃取技术,克服了中草药样品中复杂的基质干扰问题,建立超高效液相色谱-串联质谱(UPLC-MS/MS)法检测中药材中15种氨基甲酸酯类杀虫剂的残留量。方法:样品中残留的农药经乙腈提取,PSA固相萃取柱净化后,采用UPLC-MS/MS法进行测定。结果:15种农药在其各自的浓度范围内,线性关系良好,相关系数在0.995～0.999之间。在定量限(LOQ)、5倍定量限和10倍定量限3个添加浓度水平,平均加标回收率在61.8%～98.1%之间;RSD在1.8%～14.8%之间。结论:该方法操作简便,净化效果好,灵敏度高,可为中药材中氨基甲酸酯类杀虫剂污染状况调查提供检测方法支持。
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| 关 键 词： | 氨基甲酸酯类 中草药 农药残留 超高效液相色谱-串联质谱法 |
UPLC-MS/MS determination of carbamate pesticides in traditional Chinese medicine |
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| LI Na,LIU Lei,SHAO Hui,LI Hui,ZHANG Yu-ting,SONG Hai-fei,GUO Yong-ze. UPLC-MS/MS determination of carbamate pesticides in traditional Chinese medicine[J]. Chinese Journal of Pharmaceutical Analysis, 2011, 0(12) |
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| Authors: | LI Na LIU Lei SHAO Hui LI Hui ZHANG Yu-ting SONG Hai-fei GUO Yong-ze |
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| Affiliation: | LI Na,LIU Lei,SHAO Hui,LI Hui,ZHANG Yu-ting,SONG Hai-fei,GUO Yong-ze (Tianjin Academy of Agricultural Sciences,Central Laboratory,Tianjin 300381,China) |
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| Abstract: | Objective:An ultra performance liquid chromatography-tandem mass spectrometric method was developed for the determination of 15 carbamate pesticides in traditional Chinese medicine.Method:Pesticides were extracted with acetonitrile,cleaned up by PSA solid phase extraction column,and then analyzed by UPLC-MS/MS.Result:The standard calibration curves for 15 carbamate pesticides showed high correlation coefficient(0.995-0.999) over their respective concentration range.The average recovery of 15 carbamate pesti... |
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| Keywords: | carbamates traditional Chinese medicine pesticide residue UPLC-MS/MS |
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