Analysis of the 3'UTR of the prostaglandin synthetase-2 (PTGS-2/COX-2) gene in non-melanoma skin cancer after organ transplantation |
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| Authors: | Gomez-Lira Macarena Tessari Gianpaolo Mazzola Silvia Malerba Giovanni Rugiu Carlo Naldi Luigi Nacchia Francesco Valerio Francesca Anna Brunello Forni Alberto Boschiero Luigino Sandrini Silvio Faggian Giuseppe Girolomoni Giampiero Turco Alberto |
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| Institution: | 1. Section of Biology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy;2. Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy;3. Section of Nephrology, Department of Medicine, University of Verona, Verona, Italy;4. Centro Studi GISED Padiglione Mazzoleni Presidio Ospedaliero Matteo Rota, Bergamo, Italy;5. Kidney Transplantation Centre, Azienda Ospedaliero‐Universitaria Integrata di Verona, Verona, Italy;6. Section of Nephrology, Azienda Ospedaliera Spedali Civili, Verona, Italy;7. Section of Nephrology, Azienda Ospedaliera Ca Foncello, Treviso, Italy;8. Institute of Cardiac Surgery, University of Verona, Verona, Italy;9. Section of Nephrology, Azienda Ospedaliera Spedali Civili Brescia, Italy |
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| Abstract: | To define the potential involvement of polymorphisms in the 3'untranslated region (3'UTR) of the prostaglandin synthetase-2 (PTGS-2) gene to non-melanoma skin cancer (NMSC) predisposition after transplantation, we screened for genetic variant, relevant parts of this region. It contains binding sites for trans-acting factors, an alternative polyadenylation site and putative target sequences for miRNAs. Variant +8473T>C did not appear to play a functional role in the regulation of gene expression in human keratinocyte-transfected cells. In addition to the well-known +8473T>C, we identified four polymorphisms: +8293G>C, +10259T>G, +10267G>A and +10335G>A. No allele frequency differences were observed between cases and controls neither for +8473T>C nor for any of the identified polymorphisms, suggesting that polymorphisms in the 3'UTR of the PTGS2 gene are rare and unlikely to represent risk factor for NMSC after transplantation. |
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| Keywords: | 3′UTR region non‐melanoma skin cancer organ transplant recipients polymorphisms PTGS‐2 gene |
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