| Intercellular Adhension Molecule-1 in the Pathogenesis of Heroin-induced Acute Lung Injury in Rats |
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| 作者姓名： | 周琼 白明 邹世清 |
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| 作者单位： | Department of Respiratory Diseases，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Department of Respiratory Diseases，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Department of Withdrawal，Liyuan Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430072，China |
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| 摘 要： | Heroin relateddiseasehasbeenincreaseddrasti callywiththeabuseofillegaldrugsallovertheworld .Ofthecomplicationsrelatedtoheroinaddic tion ,therateamong patientswithrespiratorydis easeshasrangedfrom 2 1 %to 91 %.Earlierretro spectivecaseseriesofpatientshospi…
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| 关 键 词： | ICAM-1 ALI BALF RT-PCR RNA |
| 收稿时间： | 27 January 2003 |
Intercellular adhension molecule-1 in the pathogenesis of heroin-induced acute lung injury in rats |
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| Zhou?Qiong,Bai?Ming,Zou?Shiqing.Intercellular Adhension Molecule-1 in the Pathogenesis of Heroin-induced Acute Lung Injury in Rats[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2004,24(5):430-432. |
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| Authors: | Zhou Qiong Bai Ming Zou Shiqing |
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| Institution: | 1. Department of Respiratory Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
2. Department of Withdrawal, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430072, China |
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| Abstract: | The expression of intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of heroin-induced acute lung injury (ALI) in rats was investigated. The model of ALI was established by intravenous injection of heroin into tail vein in rats. Thirty-six rats were randomly divided into heroin-treated groups (1 h, 2 h, 4 h, 6 h and 24 h) and normal control group. Changes in histopathologic morphology and biological markers of ALI were measured. The expression of ICAM-1 in lung tissue was detected by using immunohistochemistry and RT-PCR. The results showed that the W/D ratio and protein contents in BALF of the heroin-treated groups were significantly higher than that of the control group (P<0.01). The histopathological changes in the lung tissue were more obvious in heroin-treated groups. The ICAM-1 protein and mRNA expression in the lung tissue of heroin-treated groups were significantly increased as compared with that of the control group (P<0.01), and correlated with the ALI parameters in a time-dependent manner. Increasing of ICAM-1 expression was involved in the formation of heroin-induced lung injury. Furthermore, the level of expression was positively correlated with the severity of lung injury. |
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| Keywords: | heroin acute lung injury intercellular adhesion molecule-1 |
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