| 乳腺浸润性导管癌中NRP-1的表达及其临床意义 |
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| 引用本文： | 王雅冰,生孟军. 乳腺浸润性导管癌中NRP-1的表达及其临床意义[J]. 实用预防医学, 2011, 18(7): 1277-1278 |
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| 作者姓名： | 王雅冰 生孟军 |
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| 作者单位： | 河北医科大学石油临床医学院,河北廊坊,065000 |
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| 摘 要： | 目的探讨nueropilin-1（NRP-1）在乳腺浸润性导管癌中的表达及其与临床病理特征的相关性。方法应用免疫组化EnVision法检测50例乳腺浸润性导管癌（包括有腋淋巴结转移22例及无腋淋巴结转移28例）及30例乳腺良性疾病组织中NRP-1的表达,分析其表达与患者临床病理特征之间的关系。结果乳腺癌组织中NRP-1阳性表达率明显高于乳腺纤维腺瘤和乳腺囊性增生症（P〈0.05）,乳腺浸润性导管癌患者中,NRP-1的表达强度与腋窝淋巴结转移和TNM分期密切相关（P〈0.01）。结论 NRP-1过度表达可能参与了乳腺癌发生淋巴结转移的过程。
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| 关 键 词： | 乳腺癌 nueropilin-1 淋巴结转移 |
Expression and Clinical Significance of nueropilin-1 in Breast Invasive Ductal Carcinoma |
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| WANG Ya-bing,SHENG Meng-jun. Expression and Clinical Significance of nueropilin-1 in Breast Invasive Ductal Carcinoma[J]. Practical Preventive Medicine, 2011, 18(7): 1277-1278 |
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| Authors: | WANG Ya-bing SHENG Meng-jun |
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| Affiliation: | WANG Ya-bing,SHENG Meng-jun(CNPC Central Hospital,Langfang 065000,Hebei,China) |
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| Abstract: | Objective To explore the expression of nueropilin-1 and its relationship with axillary lymph node metastasis in breast invasive ductal carcinoma.Methods The expression of nueropilin-1 was detected by immunohistochemieal EnVision method in 50 cases of breast invasive ductal carcinoma(22 cases with axillary lymph node metastasis and 28 cases without axillary lymph node involvement) and 30 cases of breast benign lesions.The relationship between nueropilin-1 expression and the patients' clinicopathological feat... |
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| Keywords: | Breast carcinoma nueropilin-1 Lymph node metastasis |
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