| 干扰素在狂犬病预防中作用的观察 |
| |
| 引用本文： | 陈立,易长庚,李金强.干扰素在狂犬病预防中作用的观察[J].实用预防医学,2011,18(7):1235-1236. |
| |
| 作者姓名： | 陈立 易长庚 李金强 |
| |
| 作者单位： | 湖南省长沙市第一医院感染科,湖南长沙,410011 |
| |
| 摘 要： | 目的回顾性观察2008年10月-2009年10月干扰素在狂犬病预防中的作用。方法观察组全疗程注射狂犬疫苗,同时首剂疫苗注射时加用α-2b干扰素200万IU伤口局部封闭注射,300万IU肌肉注射,对照组单用狂犬疫苗或狂犬疫苗加狂犬病免疫球蛋白。比较三组人均治疗费用。追踪回访各组预防处理后第45 d狂犬病抗体阳性率及12个月内狂犬病发病数。结果第45 d查狂犬病抗体,使用干扰素组抗体阳性率94.1%,单用狂犬疫苗组抗体阳性率89.0%,狂犬疫苗加狂犬病免疫球蛋白组抗体阳性率94.8%,干扰素联合狂犬疫苗组抗体阳性率显著高于单用狂犬疫苗组（χ2=40.33,P〈0.01）,与狂犬疫苗加狂犬病免疫球蛋白组差异无统计学意义（χ2=0.811,P〉0.05）。干扰素加狂犬疫苗组及狂犬疫苗加狂犬免疫球蛋白组狂犬病发病率显著低于单用狂犬疫苗组（χ2=7.301,P〈0.01）。三组进行人均价格比较,观察组费用稍高于单用狂犬疫苗组,明显低于狂犬疫苗加狂犬病免疫球蛋白组。结论干扰素联合狂犬疫苗在狂犬病的预防中可以增加抗体阳性率,减低狂犬病发生率,且费用明显低于狂犬疫苗加狂犬病免疫球蛋白组。
|
| 关 键 词： | 狂犬病 狂犬疫苗 干扰素 |
Observation on the Role of Interferon in Rabies Prevention |
| |
| CHEN Li,YI Chang-geng,LI Jin-qiang.Observation on the Role of Interferon in Rabies Prevention[J].Practical Preventive Medicine,2011,18(7):1235-1236. |
| |
| Authors: | CHEN Li YI Chang-geng LI Jin-qiang |
| |
| Institution: | CHEN Li,YI Chang-geng,LI Jin-qiang(Department of Infectious Diseases,the First Hospital of Changsha,Changsha 410011,Hunan,China) |
| |
| Abstract: | Objective To retrospectively observe the role of interferon(IFN) in the prevention of rabies through October 2008 to October 2009.Methods Rabies vaccine joint 2,000,000 IU IFNa-2b were injected in partial closure at the first agent and 3,000,000 IU IFNa-2b were intramuscularly injected in the observation group.The control group was received rabies vaccine or the rabies vaccine joint rabies immune globulin.The average therapy burden was compared among the three groups.The positive conversion rate of rabies a... |
| |
| Keywords: | Rabies Rabies vaccine IFN |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
