Percutaneous thermal ablation for the treatment of colorectal liver metastases and hepatocellular carcinoma: a comparison of local therapeutic efficacy |
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| Authors: | Ming Liu Ming Xu Fu-shun Pan Ming-de Lu Ke-guo Zheng |
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| Affiliation: | 1. Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China;2. Department of Hepatobiliary Surgery, Institute of Diagnostic and Interventional Ultrasound of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China;3. Department of Radiology of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China |
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| Abstract: | Aim: This study aimed to compare the local therapeutic efficacy of percutaneous thermal ablation for colorectal liver metastases (CRLM) and hepatocellular carcinoma (HCC).Methods: One hundred sixty-one CRLM nodules in 101 patients and 122 HCC nodules in 97 patients were treated with thermal ablation. Complications and local efficacy were retrospectively compared.Results: Major complications were observed in two (2.0%) patients in the CRLM group and one (1.0%) in the HCC group (p?=?1.000). The complete ablation (CA) rate of lesions ≤?3?cm was lower in the CRLM group than in the HCC group (p?=?0.018). After a mean follow-up period of 21.1?±?20.7 months in the CRLM group and 22.1?±?17.6 months in the HCC group, the local tumour progression (LTP) rate of lesions >?3?cm was higher in the CRLM group than in the HCC group (p?=?0.036). The multivariate analysis revealed that only safety margin (≤?0.5?cm/>?0.5?cm) was a significant predictor of LTP in both CRLM and HCC.Conclusions: To achieve better local tumour control, thermal ablation should be more aggressive for CRLM than for HCC, especially for large tumours in clinical. |
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| Keywords: | Colorectal liver metastases hepatocellular carcinoma thermal ablation local efficacy comparative study |
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