| 肝抗原自身抗体检测在自身免疫性肝病诊断中的意义 |
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| 引用本文： | 陈丽,龚丽敏,曹海芬. 肝抗原自身抗体检测在自身免疫性肝病诊断中的意义[J]. 中国卫生检验杂志, 2010, 0(1) |
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| 作者姓名： | 陈丽 龚丽敏 曹海芬 |
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| 作者单位： | 浙江省宁波市第一医院;浙江省宁波市医疗中心李惠利医院; |
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| 摘 要： | 目的:探讨自身免疫性肝脏疾病的自身抗体特征,以提高对该病的认识。方法:在85例患者中,自身免疫性肝炎(AIH)17例,原发性胆汁性肝硬化(PBC)22例,原发性硬化性胆管炎(PSC)5例,AIH/PBC重叠综合征11例,不明原因肝损伤30例。采用间接免疫荧光法和免疫印迹法分别检测抗核抗体(ANA)、抗线粒体抗体(AMA)、抗平滑肌抗体(SMA)、抗线粒体Ⅱ型抗体(AMA-M2)、抗肝肾微粒体抗体Ⅰ型(LKM-1)、抗肝胞浆I型抗体(LC-1)和抗可溶性肝抗原/肝胰抗原(SLA/LP)等。结果:自身免疫性肝炎组ANA、SMA、抗LKM-1、抗LC-1、抗SLA/LP的阳性率分别为82.3%、52.9%、11.8%、5.9%、11.8%。原发性胆汁性肝硬化组ANA、AMA、AMA-M2阳性率为86.4%、100%、95.5%。原发性硬化性胆管炎组检测出ANA2例。AIH/PBC重叠组检测出ANA7例,AMA6例,SMA2例。不明原因肝损伤组检测出ANA9例,AMA1例。结论:多数自身免疫性肝病伴有特异性自身抗体的出现,肝抗原自身抗体的检测将有助于自身免疫性肝病患者的诊断及治疗。
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| 关 键 词： | 自身免疫性肝病 自身抗体 间接免疫荧光法 免疫印迹法 |
Significance of detecting auto-antibody of liver antigens for diagnosis of autoimmune hepatic diseases |
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| CHEN Li,GONG Li-min,CAO Hai-fen. Significance of detecting auto-antibody of liver antigens for diagnosis of autoimmune hepatic diseases[J]. Chinses Journal of Health Laboratory Technology, 2010, 0(1) |
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| Authors: | CHEN Li GONG Li-min CAO Hai-fen |
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| Affiliation: | CHEN Li1,GONG Li-min1,CAO Hai-fen2 (1.Ningbo First Hospital,Ningbo 315010,China,2.Ningbo Medical Treatment Center Lihuili Hospital,China) |
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| Abstract: | Objective:To study the characteristics of autoantibodies in autoimmune liver diseases and to improve its recognition.Methods:85 patients were included in this study,among them 17 patients with autoimmune hepatitis(AIH),22 with primary biliary cirrhosis(PBC),5 with primary sclerosing cholangitis(PSC),11 with AIH/PBC overlap syndromes(AIH/PBC),30 with unknown reasons liver injury.Antinuclear antibodies(ANA),antimitochondrial antibodies(AMA) and antismooth muscle antibodies(SMA) were tested by indirect immunof... |
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| Keywords: | Autoimmune liver disease Autoantibodies Indirect immunofluorescence Immunoblot assay |
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