术前血小板与淋巴细胞比值对结直肠癌预后的影响

目的探讨术前外周血血小板/淋巴细胞比值（PLR）对结直肠癌患者预后的影响。方法回顾性分析解放军总医院普通外
科140例行结直肠癌根治术患者的临床资料，根据患者术前外周血血小板/淋巴细胞比值分为低PLR组（PLR<250）和高PLR组
（PLR≥250），采用单因素和COX回归模型分析两组患者的PLR及其它临床病理因素与5年生存率的关系。结果低PLR组的5
年生存率明显高于高PLR组（71.4% vs 51.5%；P=0.045）；单因素分析显示肿瘤位置，肿瘤浸润深度，淋巴结转移，肿瘤分期，PLR
对结直肠癌患者5 年生存率有影响；多因素分析显示PLR 是影响结直肠癌预后的独立危险因素（RR:2.213；95% CI：
1.007-4.863；P=0.0048）。结论术前PLR对结直肠癌预后评估有临床价值。

Preoperative platelet-lymphocyte ratio is an independent prognostic factor for resectable colorectal cancer

Objective To evaluate the impact of preoperative platelet-lymphocyte ratio (PLR) on the prognosis in patients with
operable colorectal cancer. Methods The clinical data of 140 patients with operable colorectal cancer were analyzed
retrospectively. According to preoperative PLR, the patients were divided into low PLR group (PLR<250) and high PLR group
(PLR≥250). The overall 5-year survival rates and the clinicopathological factors in the two groups were analyzed using
univariate analysis and COX regression model. Results The patients with a high PLR had a significantly lower overall 5-year
survival rate than those with a low PLR (71.4% vs 51.5%, P=0.045). Univariate analyses identified tumor location, the depth of
tumor invasion, lymph nodes metastasis, TMN stage, and PLR as significant risk factors for reduced overall 5-year survival. In
COX regression model, a high PLR was identified as an independent risk factor for poorer prognosis in patients with
resectable colorectal cancer (RR: 2.213; 95% CI: 1.007-4.863, P=0.0048). Conclusion Preoperative PLR can be a clinically
significant factor for assessment of prognosis of resectable colorectal cancer.