2型糖尿病患者与正常人骨密度的比较

目的　探讨2型糖尿病(T2DM)患者的骨密度(BMD)是否低于正常人。　方法　肾功能正常的T2DM患者615例,与同一地区1116名正常人的BMD比较。　结果　(1)女性 T2DM患者各年龄组腰椎和股骨Ward区的BMD均与正常人近似; 男性 T2DM患者 40 岁和 60 岁以上年龄组腰椎和股骨Ward区的BMD与正常人近似,但是50岁和70岁以上年龄组高于正常人(P<0.05)。(2)多元线形回归分析显示,影响女性T2DM患者 BMD的因素为年龄、体质指数(BMI)和总胆固醇水平,而影响男性T2DM患者的 BMD的因素为 BMI和餐后胰岛素水平。　结论　肾功能正常的T2DM患者的BMD不比正常人低。

Is bone mineral density lower in type 2 diabetic patients

Objective To investigate whether bone mineral density (BMD) of type 2 diabetic patients is lower than normal subjects or not. Method BMD of 615 diabetic patients were compared with 1116 normal subjects intergroup-matched for sex and age. Results (1)In female diabetic patients, BMD of lumbar and femoral Wards were similar to normal female subjects. In male diabetic patients, BMD of lumbar and femoral Ward were higher than normal male subjects in 50 years- (P<0.05) and 70 years- age group (P<0.05) and were similar to normal subjects in 40 years- and 60 years- age group. (2)In female diabetic patients, BMI were positively related to BMD. However, age and total cholesterol level were negatively related to BMD. In male diabetic patients, BMI and (insulin) level after glucose challenge were positively related to BMD. Conclusion BMD of type 2 (diabetic) patients with normal renal function is not lower than normal subjects.