Role for mannose binding lectin in the prevention of Mycoplasma infection |
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| Authors: | Hamvas Renata M J Johnson Marina Vlieger Arine M Ling Clare Sherriff Andrea Wade Angela Klein Nigel J Turner Malcolm W Webster A David B |
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| Institution: | MW Turner, Immunobiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom. |
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| Abstract: | Polymorphisms in exon 1 of the MBL-2 gene, resulting in reduced plasma levels of mannose binding lectin, were significantly overrepresented in 23 patients with primary antibody deficiency and culture-proven mycoplasma infections (P = 0.0038). This association persisted with the inclusion of a further nine suspected (doxycycline-responsive) cases (P = 0.0087). The lectin was shown to bind to three strains of mycoplasma. |
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