冠心病患者血清超敏C反应蛋白、肌钙蛋白、血脂水平变化及临床意义

目的:研究冠心病患者血清超敏C反应蛋白(hs-CRP)、肌钙蛋白I(cTnI)、血脂水平变化及临床意义.方法:对102例冠心病患者[稳定型心绞痛( SAP)组48例、不稳定型心绞痛(UAP)组33例、急性心肌梗死(AMI)组21例]血清hsCRP,cTnI,甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)等生化指标水平进行检测,并与正常对照组的40例健康受试者进行比较分析.结果:SAP组血清hs-CRP水平显著高于正常对照组,差异具有统计学意义(P＜0.05)；UAP组、AMI组血清hs-CRP,cTnI,TC,TG及LDL-C水平均显著高于正常对照组,HDL-C水平均显著低于正常对照组,差异均具有统计学意义(P ＜0.05)；SAP组、UAP组血清hs-CRP,cTnI,TC,TG及LDL-C水平均显著低于AMI组,HDL-C水平均显著高于AMI组,差异均具有统计学意义(P ＜0.05)；SAP组血清hs-CRP,cTnI水平显著低于UAP组,差异亦均具有统计学意义(P＜0.05);hs-CRP与TC,TG,LDL-C均呈显著正相关(P＜0.05),与HDL-C均呈显著负相关(P＜0.05),hs-CRP与cTnI之间呈显著正相关(P＜0.05).结论:检测冠心病患者血清hs-CRP,cTnI及血脂水平对患者疾病预测及治疗具有重要的临床意义.

Clinical Significance of Detecting Serum Levels of Hs-CRP, CTnI and Blood Lipids in Patients with Coronary Heart Disease

Objective: To study the clinical significance of detecting serum levels of high-sensitivity C-reactive protein(hs-CRP), cardiac troponin I(cTnI) and blood lipids in patients with coronary heart disease (CHD). Method: The serum levels of hs-CRP, cTnI, triglycerides(TG), total cholesterol(TC), low-density lipoprotein(LDL-C), high-density lipoprotein cholesterol(HDL-C) were detected in one hundred and two patients, and compared with those of 40 healthy subjects in the control group. Result: The serum level of hs-CRP in the stable angina pectoris(SAP) group was significantly higher than in the control group (P<0.05). The serum levels of hs-CRP, cTnI, TC, TG, LDL-C in the unstable angina pectoris(UAP) group and the AMI group were significantly higher than those in the control group (all P <0.05), and the serum level of HDL-C was significantly lower than that in the control group (all P <0.05). The serum levels of hs-CRP, cTnI, TC, TG, LDL-C in the SAP group and the UAP group were significantly lower than those in the AMI group (all P <0.05), and the serum levels of HDL-C in the SAP group and the UAP group were significantly higher than those in the AMI group (all P <0.05). The serum levels of hs-CRP, cTnI in the SAP group were significantly lower than those in the UAP group (all P <0.05). The serum level of hs-CRP was positively correlated with TC, TG, LDL-C(P<0.05), and was negatively correlated with HDL-C (P<0.05). The serum level of hs-CRP was positively correlated with cTnI (P<0.05). Conclusion: The detection of serum levels of hs-CRP, cTnI and blood lipids plays an important role in disease prediction and treatment of patients with CHD.