联合检测慢性肾功能衰竭患者血清肝纤维化指标及Cys C水平的临床应用

目的探讨联合检测血清肝纤维化指标与血清胱抑素(Cys C)在慢性肾功能衰竭(CRF)患者中的临床应用价值。方法 CRF组55例,健康对照组32例,采用放射免疫分析法检测血清透明质酸(HA)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(C-Ⅳ)层黏连蛋白(LN)水平,同时采用全自动生化仪检测血清Cys C、尿素氮(BUN)、肌酐(Cr)。结果 CRF组患者HA、PC-Ⅲ、C-Ⅳ、LN分别为(316.47±48.69)、(258.42±49.74)、(110.79±22.45)、(142.11±28.16)ng/mL,血清Cys C为(3.83±1.28)ng/mL。健康对照组HA、PC-Ⅲ、C-Ⅳ、LN水平则分别为(85.43±20.68)、(76.52±40.12)、(62.28±18.72)和(106.08±27.13)ng/mL,血清Cys C为(0.86±0.18)mg/mL,除LN外,其他指标CRF组明显高于健康对照组,差异有统计学意义(P<0.01)。结论联合检测血清肝纤维化指标及血清Cys C比单项检测对于CRF患者的早期诊断及疗效观察更有临床意义。

Evaluation of the clinical value of combined detection of serum fibrosis indexes and cystatin C in chronic renal failure

Objective To evaluate the clinical value of combined detection of serum fibrosis index and cystatin C（Cys C）in chronic renal failure（CRF）.Methods 55cases of CRF and 32cases of healthy subjects were enrolled and detected for serum hyaluronic acid（HA）,procollagen typeⅢ（PC-Ⅲ）,collagen typeⅣ（C-Ⅳ）and laminin（LN）by using radio immunoassay,and for serume Cys C,blood urea nitrogen（BUN）and creatinine（Cr）by using automatic biochemical analyzer.Results The levels of HA,PC-Ⅲ,C-Ⅳ,LN and Cys C in CRF group were（316.47±48.69）,（258.42±49.74）,（110.79±22.45）,（142.11±28.16）and（3.83±1.28）ng/mL,respectively,and those in control group were（85.43±20.68）,（76.52±40.12）,（62.28±18.72）,（106.08±27.13）and（0.86±0.18）ng/mL,respectively.Except LN,levels of other indexes were significantly higher in CRF group than control group（P0.01）.Conclusion Compared with single detection,combined detection of serum fibrosis indexes and Cys C could be more clinically significant for the early diagnosis and therapeutic efficacy judgment of CRF.