利福喷丁联合左氧氟沙星治疗初治菌阳肺结核近期疗效观察

目的 探讨利福喷丁联合左氧氟沙星治疗方案对初治菌阳肺结核的疗效.方法 将本院收治的96例初治菌阳肺结核患者随机分为对照组和治疗组各48例,分别给予2HRZE/4HRE和2HL2ZV/4HL2V治疗方案,在治疗2月、6月末比较两组患者痰菌阴转率、病灶吸收和空洞愈合情况.结果 治疗2月、6月末,治疗组痰菌阴转率为91.67%和100%、病灶吸收好转率为54.17%和77.08%、空洞愈合率为32.35%和55.88%;对照组明菌阴转率为72.92%和89.58%、病灶吸收好转率为37.50%和54.17%、空洞愈合率为12.5%和31.25%.两组之间以上指标比较,差异有统计学意义（P＜0.05）.结论 利福喷丁联合左氧氟沙星方案治疗初治菌阳肺结核疗效满意.

Observation of curative effect of rifapentine combined with levofloxacin in the treatment of initial treated sputum positive pulmonary tuberculosis

Objective To explore the efficacy of rifapentine combined with levofloxacin in the treatment of patients with initial treated sputum positive pulmonary tuberculosis. Methods 96 patients with initial treated sputum positive pulmonary tuberculosis from March 2004 to December 2012 were randomly divided into the control group and the treatment group, 48 cases each. The control group was given 2HRZE/4HRE, and the treatment group was given 2HL2ZV/4HL2V. Sputum conversion rate, lesion absorption and void heal- ing were compared 2 and 6 months after the treatment between the two groups. Results 2 and 6 months after the treatment, the sputum conversion rate was 91.67% and 100%, the lesions absorption rate was 54. 17% and 77.08%, and the void healing rate was 32.35% and 55.88% in the treatment group. The negative conversion rate was 72.92% and 89.58%, the lesions absorption rate was 37.50% and 54. 17%, and void healing rate was 12.5% and 31.25%. There were significant differences on those indicators between the two groups （ P 〈 0. 05 ）. Conclusion Rifapentine combined with levofloxacin has satisfactory curative effect in the treatment of initial treated sputum positive pulmonary tuberculosis.