Role of sympathetic nerve and adrenal gland in the potentiation of hypoxic pulmonary vasoconstriction during cigarette smoking |
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Authors: | Wang Wei-han Wang Di-xun |
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Institution: | (1) Department of Pathophysiology, Tongji Medical University, Wuhan |
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Abstract: | Summary The aim of this study was to investigate the role of sympathetic nerve and adrenal gland in the changes in hemodynamics and
hypoxic pulmonary vasoconstriction (HPV) induced by cigarette smoking in Wistar rats. Data showed that an increment of pulmonary
vascular resistance (PVR) induced by alveolar hypoxia was partially prevented by prazosin (α1-receptor blocker) and prazosin combined with propranolol (β-receptor blocker), but not significantly affected by propranolol
or adrenalectomy. Cigarette smoking tould increase PVR and potentiate HPV, whereas the potentiation of HPV was partially inhibited
by prazosin and strengthened by propranolol, but not affected by adrenalectomy. It is suggested that the sympathetic nerve
excitation caused by cigarette smoking may play a role in the strengthening of HPV. |
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Keywords: | hypoxic pulmonary vasoconstriction cigarette smoking sympathetic nerve adrenal gland |
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