Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides. |
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| Authors: | J A Secrist K N Tiwari J M Riordan J A Montgomery |
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| Affiliation: | Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35255-5305. |
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| Abstract: | 2'-Deoxy-4'-thiocytidine (7 beta), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in cell culture. |
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