Potentiation of ethanol withdrawal by prior dependence |
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Authors: | Timothy B. Baker Dale S. Cannon |
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Affiliation: | (1) Salt Lake Veterans Administration Hospital, 84148 Salt Lake City, Utah, USA |
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Abstract: | Thirty rats were randomly assigned to three groups. Group 1 was given a 21-day exposure to an ethanol (EtOH) liquid diet, while Groups 2 and 3 were given equivalent amounts of an isocaloric non-EtOH liquid diet. Group 1 rats had withdrawal syndromes following EtOH removal. After a two-week recovery period, Groups 1 and 2 were both exposed to an EtOH diet, while Group 3 again received an isocaloric non-EtOH liquid diet. Groups 1 and 2 were withdrawn after 12 days of EtOH exposure and were rated with a behavioral withdrawal rating scale, for which interobserver reliability estimates were determined. Previously dependent (Group 1) rats showed more severe withdrawal syndromes, including a higher incidence of seizures, than rats undergoing their initial withdrawal (Group 2). Studies that do not agree with this finding are discussed.Address for offprint requests: Alcohol Research (3D), Veterans Administration Hospital, Salt Lake City, Utah 84148, U.S.A. |
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Keywords: | Ethanol withdrawal Convulsions Blood ethanol concentrations Tolerance to ethanol Rats |
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