| 缝隙连接蛋白43的表达与神经管畸形的关系研究 |
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| 引用本文： | 马永臻.缝隙连接蛋白43的表达与神经管畸形的关系研究[J].山东医学高等专科学校学报,2011,33(1):1-3,81. |
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| 作者姓名： | 马永臻 |
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| 作者单位： | 山东医学高等专科学校,山东临沂,276000 |
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| 基金项目： | 临沂市科技发展计划项目 |
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| 摘 要： | 目的观察缝隙连接蛋白43(Cx43)在神经管周围间充质细胞的表达,以探讨Cx43与神经管畸形(NTDs)发生的关系。方法用维甲酸(RA)建立昆明小鼠神经管畸形模型,用免疫组化方法分析比较实验组和对照组神经管发育情况以及Cx43蛋白表达的位置和强度。结果对照组神经管发育良好,实验组神经管不能按时闭合;Cx43蛋白表达于神经管周围间充质细胞的胞膜和胞质内,而且实验组明显高于对照组(P<0.05)。结论 Cx43蛋白的过高表达可能与RA致NTDs密切相关。
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| 关 键 词： | 缝隙连接蛋白43 神经管畸形 维甲酸 免疫组织化学 |
STUDY OF THE RELATIONSHIP BETWEEN EXPRESSION OF CONNEXIN 43 AND NEURAL TUBE DEFECTS |
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| MA Yong-zhen.STUDY OF THE RELATIONSHIP BETWEEN EXPRESSION OF CONNEXIN 43 AND NEURAL TUBE DEFECTS[J].Journal of Shandong Medical College,2011,33(1):1-3,81. |
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| Authors: | MA Yong-zhen |
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| Institution: | MA Yong-zhen(Shandong Medical College,Linyi,China 276000) |
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| Abstract: | Objective To investigate the expression of Connexin 43(Cx43) in mesenchymal cell around the neural tube and to explore its role in the pathogenesis of neural tube defects(NTDs).Methods To set up NTDs model in mouse embryo by overdose ratinoic acid(RA).To analyze and compare the neural tube developmental condition and expressed position and intension of Cx43 between the control group and the experimental group by SABC immunohistochemistry methods and the image processing system.Results The neural tube in con... |
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| Keywords: | Connexin43 Neural tube defects Immunohistochemistry |
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