| 绿僵菌的急性毒性及致敏实验观察 |
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| 引用本文： | 刘志勇,周银平,李启富,戴黎光,周明,田泽敏,刘琳,包锦英,喻荣珍,杨新跃.绿僵菌的急性毒性及致敏实验观察[J].江西医学院学报,2004,44(3):30-32. |
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| 作者姓名： | 刘志勇 周银平 李启富 戴黎光 周明 田泽敏 刘琳 包锦英 喻荣珍 杨新跃 |
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| 作者单位： | 江西省劳动卫生职业病防治研究所 江西南昌330006
(刘志勇，周银平，李启富，戴黎光，周明，田泽敏，刘琳，包锦英，喻荣珍)，江西省劳动卫生职业病防治研究所 江西南昌330006(杨新跃) |
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| 摘 要： | 目的 研究生物农药绿僵菌 (Metarhizium)原药急性经口、经皮、吸入毒性及眼睛刺激和致敏率。方法 按照《农药登记毒理学试验方法》(GB15 6 70 1995 )进行操作。结果 该受试物对雌、雄性大鼠急性经口LD50 >5 0 0 0mg/kg ;对雌、雄性大鼠急性经皮LD5 0 (4h) >2 15 0mg/kg ;对雄、雌性大鼠急性吸入LC50 (2h) >5 0 0 0mg/m3 ;对实验兔急性眼平均刺激指数为 0 ;对豚鼠致敏率为 0 %。结论 该受试物急性经口属微毒性、急性经皮属低毒性、急性吸入属微毒性 ,眼睛刺激试验为无刺激性 ,致敏试验属Ⅰ级弱致敏物
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| 关 键 词： | 绿僵首原药 急性毒性实验 致敏实验 生物农药 |
| 文章编号： | 1000-2294(2004)02-0030-03 |
| 修稿时间： | 2003年12月8日 |
The Acute Toxicity and Dermal Sensitisation of Metarhizium Original Drug |
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| LIU Zhi-yong,ZHOU Yin-ping,LI Qi-fu,DAI Li-guang,ZHOU Ming,TIAN Ze-min,LIU Lin,BAO Jin-ying,YU Rong-zhen,YANG Xin-yue.The Acute Toxicity and Dermal Sensitisation of Metarhizium Original Drug[J].Acta Academiae Medicinae Jiangxi,2004,44(3):30-32. |
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| Authors: | LIU Zhi-yong ZHOU Yin-ping LI Qi-fu DAI Li-guang ZHOU Ming TIAN Ze-min LIU Lin BAO Jin-ying YU Rong-zhen YANG Xin-yue |
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| Abstract: | Objective To test the acute toxicity of biopesticide-Metarhizium, include oral toxicity, dermal toxicity, inhalation toxicity, eye irritation and dermal sensitization.Methods The toxicological test methods of pesticides for registration(GB15670-1995) was employed.Results The acute oral toxicity of this biopesticide-Metarhizium was LD 50>5000 mg/kg, acute dermal toxicity LD 50(4 h)>2150 mg/kg, LC 50(2 h)>5000 mg/m 3, there was noirrtation to rabbit eye,dermal sensitiztion:rate of sensitization was zero.Conclusion This biopesticide-Metarhizium acute oral toxicity, acute dermal toxicity and acute inhalation toxicity are lower toxicity. There is no irritation to rabbit eye, and it belongs to grad I weak sensitizing matter. |
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| Keywords: | acute toxicity dermal Sensitisation biopesticide |
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