舒血宁注射液治疗冠心病左室舒张功能不全的临床研究

目的观察舒血宁注射液治疗冠心病左室舒张功能不全的临床疗效。方法将90例冠心病左室舒张功能不全患者随机分为对照组和试验组(每组45例),2组均给予基础治疗,试验组加用舒血宁注射液20mL,疗程2周。观察治疗前后2组舒张早期最大血流速度(E峰)、舒张晚期最大血流速度(A峰)、峰值速度比值(E/A)、左室射血分数(LVEF)的变化及总体疗效。结果治疗后2组临床症状均有好转。试验组的总有效率高于对照组,优效性检验成立。同时,治疗组舒张功能指标E/A比值、A峰、E峰改善优于对照组。结论舒血宁注射液能明显改善冠心病左室舒张功能不全者的临床症状和心功能指标。

Clinical Study on Left Ventricular Diastolic Dysfunction Treated by Shuxuening Injection

Objective To study the effect of Shuxuening injection on treatment of left ventricular diastolic dysfunction. Methods Ninety cases of left ventricular diastolic dysfunction were divided into control group and test group randomly, 45 cases for each group. Both groups were treated with standard management and the treatment group was given Shuxuening injection （20 mL） additionally for 2 weeks. E/A ratio, peak E, peak A, LVEF were observed before and after treatment. Result The clinical symptoms of the two groups were all improved after treatment. The test group had a higher overall effective rate than the control group. The ventricular diastolic function paramenters （E/A ratio, peak E, peak A, LVEF） in the test group were much better than that in the control group. Conclusion Shuxuening injection can improve the clinical symptoms and signs of left ventricular diastolic dysfunction.