Hypoxic modulation of striatal lesions induced by administration of endothelin-1 |
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| Authors: | Park L Thornhill J |
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| Institution: | Department of Physiology and Saskatchewan Stroke Research Center, University of Saskatchewan, 107 Wiggins Road, Saskatoon, S7N 5E5, Saskatchewan, Canada. park@duke.usask.ca |
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| Abstract: | Levels of endothelin-1 (ET-1), a potent endogenous vasoconstrictor, are elevated in plasma and cerebrospinal fluid (CSF) following cerebral ischemia and reperfusion injury. The present study sought insight into the potential differential vasoactive effects on the cerebral vasculature and resultant neural damage of ET-1 during normoxic vs. ischemic conditions and upon reperfusion. Under normoxic conditions, intrastriatal stereotaxic injection of exogenous ET-1 (40 pmol) induced a significant (P<0.05) reduction (
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| Keywords: | Endothelin Hypoxia Laser Doppler flowmetry Reoxygenation Neural damage |
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