EEG mapping of left hemisphere dysfunction during motor performance in schizophrenia |
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| Authors: | W Guenther D Breitling J P Banquet P Marcie P Rondot |
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| Affiliation: | 1. Stony Brook University Department of Psychology, Stony Brook, NY, United States of America;2. Stony Brook Medicine, Psychiatry Department, Stony Brook, NY, United States of America;3. Purdue University Department of Psychological Sciences, West Lafayette, IN, United States of America;1. Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA;2. Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA;3. Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA, USA;1. Department of Physical Therapy, University of British Columbia, Vancouver, BC V6T 1Z3, Canada;2. Stroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3084, Australia;3. NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery, Australia |
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| Abstract: | With a newly developed system of brain electrical activity mapping we studied 10 right-handed, neuroleptic-treated schizophrenics (five of the disorganized, five of the paranoid type, corresponding to 295.1 and .3 in DSM-III), compared with 10 normal controls. Increasingly complex motor tasks were used for cortical activation, all functional states being referenced to resting states recorded after a special relaxation program. We found higher delta and theta amplitudes during rest, as noted in previous studies, and lower beta power values. As a major result, however, we found a widespread left hemisphere dysfunction in schizophrenics, predominantly in the left primary sensory and motor areas. Additionally, we found signs of a "compensatory" overactivation in patients in motor tasks, when this hemisphere is not "used" by normal persons. The results support our findings obtained with this method during multisensory motor coordination in schizophrenia. The results in these patients suggest that these are not merely vigilance, attention, or motivation dysfunctions, but rather specific cortical correlates of impaired motor performance. |
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