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| 骨髓间充质干细胞对股骨头坏死缺损模型修复的组织学观察 | |
| 引用本文： | 孙伟,李子荣,史振才,张念非,李艳,崔福斋,张岚,蔡哲. 骨髓间充质干细胞对股骨头坏死缺损模型修复的组织学观察[J]. 中国康复理论与实践, 2005, 11(1): 4-6 |
| 作者姓名： | 孙伟 李子荣 史振才 张念非 李艳 崔福斋 张岚 蔡哲 |
| 作者单位： | 1. 100029,北京市,中日友好医院骨科骨坏死与关节保留重建中心 2. 100084,北京市,清华大学材料科学与工程系 3. 100029,北京市,中日友好临床医学研究所免疫室 |
| 基金项目： | 首都医学发展科研基金重大科技联合攻关项目 (2 0 0 2 1 0 0 7)，卫生部属 (管 )医疗机构临床学科重点项目。 |
| 摘 要： | 目的研究骨髓间充质干细胞在治疗股骨头坏死动物模型的修复作用及价值。方法建立兔双侧股骨头内骨缺损模型，并分为3组，A组为制作缺损而不填充任何材料，B组为单纯填充纳米人工骨，C组填充纳米人工骨和骨髓间充质干细胞的复合材料。对植入后4周、8周、12周的股骨头行组织学检查。结果B组和C组在股骨头缺损修复成骨方面与A组有显著差异，C组差异性更大。结论骨髓间充质干细胞有较强的成骨作用，可促进股骨头坏死骨缺损的修复，对股骨头坏死的治疗有较大价值。 |
| 关 键 词： | 股骨头坏死 骨缺损 骨髓间充质干细胞 兔 |
| 文章编号： | 1006-9771(2005)01-0004-03 |
| 修稿时间： | 2004-12-14 |
Histological observation on repair of bone mesenchymal stem cell in rabbit osteonecrosis of the femoral head defect model |
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| SUN Wei,LI Zi rong,SHI Zhen cai,et al.. Histological observation on repair of bone mesenchymal stem cell in rabbit osteonecrosis of the femoral head defect model[J]. Chinese Journal of Rehabilitation Theory and Practice, 2005, 11(1): 4-6 | |
| Authors: | SUN Wei LI Zi rong SHI Zhen cai et al. |
| Affiliation: | SUN Wei,LI Zi rong,SHI Zhen cai,et al.Center for Osteonecrosis and Joint Preserving & Reconstruction,Department of Orthopaedic Surgery,China Japan Friendship Hospital,Beijing 100029,China |
| Abstract: | ObjectiveTo evaluate the effectiveness of mesenchymal stem cell (MSC) in osteonecrosis of the femoral head defect(ONFH) repair. MethodsAniaml model of ONFH defect were established with rabbits, which were divided into 3 groups, group A did not infill anything as control, nano Hydroxyapatite/collagen(nHAC) as group B, nHAC+MSC as group C. Histology change were investigated 4,8,12 weeks after operation respectively.Results groups B and C were different with group A. The difference between groups A and C was more significant. ConclusionMesenchymal stem cell has a strong activity of osteoconduction, it has a value in repairing the bone defect of ONFH and the treatment of ONFH. [ |
| Keywords: | osteonecrosis of the femoral head bone defect bone mesenchymal stem cell rabbit |
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