降钙素原联合C反应蛋白、白细胞诊断新生儿感染性肺炎临床分析

目的：研究降钙素原（PCT）联合C反应蛋白（CRP）、白细胞（WBC）诊断新生儿感染性肺炎的临床影响。方法：选取2012年7月～2014年7月我院收治的110例患有感染性肺炎的新生儿作为观察组，其中细菌性感染患儿55例，病毒性感染患儿55例，随机选取无任何感染性疾病的新生儿55例作为对照组，抽取静脉血诊断降钙素原、C反应蛋白、白细胞，观察并比较3组间的PCT、CBP、WBC水平。结果：观察组中细菌感染患儿的PCT水平（0.81±0.25）ng/ml，CRP水平（22.53±3.28）mg/L，WBC水平（16.86±2.63）×109/L，病毒性感染患儿的PCT水平（0.57±0.37）ng/ml，CRP水平（9.35±2.63）mg/L，WBC水平（10.51±2.45）×109/L，对照组中PCT水平（0.31±0.34）ng/ml，CRP水平（5.23±2.21）mg/L，WBC水平（6.53±2.41）×109/L。三组比较组间水平差异显著，具有统计学意义（P<0.05）；两两比较，细菌感染组水平高于病毒感染组与对照组患儿，差异显著，具有统计学意义（P<0.05）；且病毒感染组水平高于对照组，差异显著，具有统计学意义（P<0.05）。细菌感染组中：PCT敏感度为82.80%，特异度为91.40%，CRP敏感度为69.80%，特异度为46.30%，WBC敏感度为40.20%，特异度为34.60%；病毒感染组中：PCT敏感度为59.70%，特异度为71.60%，WBC敏感度为39.50%，特异度为31.30%，联合诊断敏感度为16.90%，特异度为21.40%。结论：采用降钙素原联合C反应蛋白、白细胞诊断新生儿感染性肺炎具有良好的敏感度、特异度，能有效帮助医生确切诊断细菌性感染或病毒性感染，在临床上值得推广应用。

Procalcitonin and C-reactive protein combined with clinical analysis of neonatal pneumonia diagnosis leukocytes

Objective: To study procalcitonin(PCT)combined with C-reactive protein(CBP), white blood cell(WBC) diagnosis of the clinical impact of neonatal pneumonia infection. Methods: Neonatal July 2012 to July 2014 in our hospital 110 cases of infection with pneumonia as the observation group, including 55 cases of children with bacterial infections, viral infections in children 55 cases randomly selected without any neonatal infectious disease as the control group 55 cases, extraction cubital vein diagnosis procalcitonin, C-reactive protein, white blood cells, were observed and compared among the three groups of PCT, CBP, WBC levels. Results: The PCT levels in children with bacterial infection(0.81±0.25)ng/ml, CRP levels(22.53±3.28)mg / L, WBC levels(16.86±2.63)×109/L, children with viral infections PCT levels(0.57±0.37)ng/ml, CRP levels(9.35±2.63)mg / L, WBC levels(10.51±2.45)×109/L, PCT levels in the control group(0.31±0.34)ng/ml, CRP levels(5.23±2.21)mg/L, WBC levels(6.53 ±2.41)×109/L. Group level among the three groups were significantly different, with statistical significance (P<0.05); pairwise comparison, bacterial infection group was higher than in childreninfected with the control group, the difference was significant, with statistical significance (P<0.05);and the viral infection level higher, the difference is remarkable, with a statistically significant (P<0.05). Bacterial infection group: PCT sensitivity of 82.80% and a specificity of 91.40%, CRP sensitivity of 69.80% and a specificity of 46.30%, WBC sensitivity of 40.20% and a specificity of 34.60%;virus group:PCT sensitivity of 59.70%and a specificity of 71.60%, WBC sensitivity of 39.50%and a specificity of 31.30%, 16.90%joint diagnostic sensitivity and specificity of 21.40%. Conclusion: The use of procalcitonin joint C-reactive protein, white blood cell diagnosis of neonatal pneumonia has good sensitivity, specificity, and can effectively help doctors diagnose the exact bacterial infection or viral infection, should be widely applied in clinical practice.