| 帕罗西汀合用阿立哌唑或喹硫平治疗难治性抑郁的对照研究 |
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| 引用本文： | 张建.帕罗西汀合用阿立哌唑或喹硫平治疗难治性抑郁的对照研究[J].中国民康医学,2011,23(23):2912+2974. |
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| 作者姓名： | 张建 |
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| 作者单位： | 徐州精神病院,江苏徐州,221003 |
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| 摘 要： | 目的:探讨阿立哌唑或喹硫平治疗难治性抑郁症的疗效与安全性。方法:48例服用帕罗西汀的难治性抑郁症患者分为阿立哌唑组(24例)和喹硫平组(24例),观察8周。于治疗前和治疗1周、4周及8周末采用汉密尔顿抑郁量表(Hamilton depressive scale,HAMD-17)评定疗效,用不良反应量表(Hamilton depressive scale,TESS)评定不良反应。结果:阿立哌唑组显效率为29.2%,喹硫平组为37.5%。喹硫平组第4周HAMD评分低于阿立哌唑组,差异有显著性。喹硫平组不良反应较少。结论:喹硫平合并帕罗西汀治疗难治性抑郁的疗效好,起效快,且不良反应少。
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| 关 键 词： | 难治性抑郁 帕罗西汀 喹硫平 阿立哌唑 |
Efficacy of Paroxetine with Quetiapine or Risperidone in the treatment of refractory depression |
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| ZHANG Jian.Efficacy of Paroxetine with Quetiapine or Risperidone in the treatment of refractory depression[J].medical journal of chinese peoples health,2011,23(23):2912+2974. |
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| Authors: | ZHANG Jian |
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| Institution: | ZHANG Jian(Xuzhou mental hospital,Jiangsu 221000,China) |
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| Abstract: | Objective:To explore the efficacy and safety of Aripiprazole and Quetiapine in the treatment of refractory depression.Methods:48 patients with refractory depression treating of Paroxetine were divided into Aripiprazole group(n=24) and Quetiapine group(n=24) observed for 8 weeks.Hamilton depressive scale(HAMD-17) and Hamilton depressive scale(TESS) were used to evaluate the efficacy and side effects at the end of 1,4,8 week.Results: The response rate of Aripiprazole group and Risperidone group were 29.2% and... |
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| Keywords: | Refractory depression Quetiapine Aripiprazole Paroxetine |
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