A型肉毒毒素治疗三叉神经痛

目的:观察A型肉毒毒素治疗三叉神经痛(TN)的临床疗效。方法:选取57例TN患者,随机分为A、B 2组。A组28例患者口服卡马西平片治疗;B组29例在疼痛部位及板机点周围皮下注射肉毒素治疗。治疗后1,3及6个月时随访,行简式McGill疼痛问卷表(SF-MPQ)及生活质量评价量表(SF-36)评分,并观察不良反应。结果:治疗中脱失7例,A组3例,B组4例。与治疗前3个月SF-MPQ及SF-36平均分作为基础水平比较,治疗1,3及6个月后2组SF-MPQ评分明显下降,SF-36明显上升(P<0.01),B组表明更明显(P<0.05,P<0.01)。治疗过程中,A组出现不适患者多于B组。结论:A型肉毒毒素疼痛点皮下注射治疗TN发作作用高峰1～3个月,维持时间6个月,且临床疗效显著,不良反应轻微。

Botulinum Toxin Type A for the Treatment of Trigeminal Neuralgia

Objective： To observe the clinical efficacy of botulinum toxin type A（BTX-A） for trigeminal neuralgia.Methods： Forty-seven cases of trigeminal neuralgia were randomly divided into two groups,receiving Carbamazeping tabs（control group,A）,and subcutaneous injection of BTX-A（therapy group,B）,respectively.The onset of trigeminal neuralgia,severity of trigeminal neuralgia,as well as side effects in patients with trigeminal neuralgia were recorded by the use of questionnaire,and compared before and 6 months after treatment.Results： The short form McGill Pain Questionnaire and Quality of Life Scale scores were significantly different before and 1,3 and 6 months after treatment in both two groups.There was significant difference in the short form McGill Pain Questionnaire and Quality of Life Scale scores between groups A and B 1,3 and 6 months after treatment（P0.05）.Conclusion： BTX-A has therapeutic effects on trigeminal neuralgia with few side effects.