Effect of Helicobacter pylori infection on Bax protein expression in patients with gastric precancerous lesions |
| |
Authors: | Liu Hai-Feng Liu Wei-Wen Wang Guo-An Teng Xiao-Chun |
| |
Institution: | 1. Department of Gastroenterology, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China 2. Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China |
| |
Abstract: | AIM: To investigate the effect of Helicobacter pylori (H pylori) infection on Bax protein expression, and explore the role of H pylori in gastric carcinogenesis. METHODS: H pylori was assessed by rapid urease test and Warthin-Starry method, and expression of Bax protein was examined immunohistochemically in 72 patients with pre-malignant lesions. RESULTS: Bax protein was differently expressed in intestinal metaplasia and gastric dysplasia, and showed 63.99% positivity. The positivity of Bax protein expression in Hpylori-positive gastric precancerous lesions (72.3%) was significantly higher than that in H pylori-negative gastric precancerous lesions (48.0%, X~2=4.191, P<0.05). H pylori infection was well correlated with the expression of Bax protein in gastric precancerous lesions (r=0.978, P<0.01). After eradication of H pylori, the positivity of Bax protein expression significantly decreased in H pylort-positive gastric precancerous lesions (X~2=5.506, P<0.05). In the persisting H pylori-infected patients, the positivity of Bax protein expression was not changed. CONCLUSION: H pylori infection may be involved in the upregulation of Bax gene, which might be one of the mechanisms of H pylori infection-induced gastric epithelial cell apoptosis. H pylori might act as a tumor promoter in the genesis of gastric carcinoma and eradication of H pylori could inhibit gastric carcinogenesis. |
| |
Keywords: | Helicobacter pylori Bax protein Gastric precancerous lesions |
本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录! |
|