| 喉癌中PTTG的表达及其与bFGF和微血管密度的关系 |
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| 引用本文： | 梁昆,姚磊,马超,孙睿杰,陆忠华,雷大鹏,潘新良. 喉癌中PTTG的表达及其与bFGF和微血管密度的关系[J]. 山东医大基础医学院学报, 2009, 0(2): 15-19 |
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| 作者姓名： | 梁昆 姚磊 马超 孙睿杰 陆忠华 雷大鹏 潘新良 |
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| 作者单位： | 山东大学齐鲁医院耳鼻咽喉头颈外科;山东大学卫生部耳鼻喉科学重点实验室; |
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| 摘 要： | 目的探讨喉癌中PTTG、bFGF的表达以及在新生血管生成过程中的作用。方法应用免疫组化SP法分别检测57例喉癌、26例癌旁和9例正常喉黏膜中PTTG、bFGF蛋白的表达,用CD34标记并计数肿瘤内微血管密度。结果喉癌中PTTG蛋白和bFGF蛋白表达率分别为84.2%和78.9%,明显高于癌旁及正常喉黏膜的表达率（P〈0.05）。PTTG的表达与肿瘤分化程度、临床分期相关和淋巴结转移差异有统计学意义（P〈0.05）,bFGF的表达与肿瘤分化程度和淋巴结转移差异有统计学意义（P〈0.05）,与临床分期差异无统计学意义（P〉0.05）。两者的表达均与患者年龄、性别和肿瘤原发部位差异无统计学意义（P〉0.05）,且两者之间呈显著正相关（P〈0.05）。喉癌中MVD值明显大于癌旁和正常喉黏膜（P〈0.05）,并与淋巴结转移显著相关（P〈0.05）,MVD分别与PTTG和bF-GF的表达相关（P〈0.05）。结论PTTG和bFGF的表达与喉癌的临床病理学特征密切相关,二者的检测将有助于喉癌的诊断、评估喉癌患者的恶性程度。
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| 关 键 词： | 喉肿瘤 垂体肿瘤转化基因 碱性成纤维细胞生长因子 微血管密度 免疫组织化学 |
Expressions of PTTG and bFGF proteins and their relationship to MVD in laryngeal carcinoma |
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| LIANG Kun,YAO Lei,MA Chao,SUN Rui-jie,LU Zhong-hua,LEI Da-peng,PAN Xin-liang. Expressions of PTTG and bFGF proteins and their relationship to MVD in laryngeal carcinoma[J]. Journal of Preclinical Medicine College of Shandong Medical University, 2009, 0(2): 15-19 |
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| Authors: | LIANG Kun YAO Lei MA Chao SUN Rui-jie LU Zhong-hua LEI Da-peng PAN Xin-liang |
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| Affiliation: | 1.Department of Otorhinolaryngology & Head and Neck Surgery;Qilu Hospital of Shandong University;Jinan 250012;China;2.Key Laboratory of Otorhinolaryngology;Ministry of Health;Shandong University;China |
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| Abstract: | Objective To explore expressions of the pituitary tumor-transforming gene(PTTG) and basic fibroblast growth factor(bFGF) proteins and their relationship to MVD in laryngeal carcinoma.Methods Expressions of PTTG and bFGF were determined by the immunohistochemical SP method in 57 cases of laryngeal carcinoma,and compared with those in 26 cases of para-carcinoma tissues and 9 cases of normal tissues.MVD in laryngeal carcinoma was evaluated by immunohistochemical staining with antibody CD34.Results The positive... |
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| Keywords: | Laryngeal neoplasm Pituitary tumor transforming gene Basic fibroblast growth factor Density of microvessels Immunohistochemistry |
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