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Cognition in Mouse Models of Schizophrenia Susceptibility Genes
Authors:P. Alexander Arguello   Joseph A. Gogos
Affiliation:2Department of Neuroscience;3Department of Physiology and Cellular Biophysics, Columbia University Medical Center, 630 W. 168th Street, New York, NY 10032
Abstract:Cognitive deficits are core features of psychiatric disorders and contribute substantially to functional outcome. It is still unclear, however, how cognitive deficits are related to underlying genetic liability and overt clinical symptoms. Fortunately, animal models of susceptibility genes can illuminate how the products of disease-associated genetic variants affect brain function and ultimately alter behavior. Using as a reference findings from the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia program and the SchizophreniaGene database, we review cognitive data from mutant models of rare and common genetic variants associated with schizophrenia.
Keywords:CNTRICS   MATRICS   executive control   working memory   22q11   DISC1
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