恶性血液病患者感染调查研究

目的了解恶性血液病(HM)患者合并感染的临床特点。方法回顾性分析2004年住院接受化疗的327例HM患者的感染发生情况。结果感染发生率为33.64%;感染部位以呼吸道最多见,占40.85%;分离的病原菌主要是革兰阴性菌(43.33%)、革兰阳性菌(33.33%)和真菌(23.34%);急性白血病和各类复发的HM患者感染率最高,达70.58%;粒细胞缺乏与无粒细胞缺乏者感染率分别是69.39%和18.64%,两者差异有显著性(P<0.05)。结论HM患者感染率高,尤以急性白血病和各类复发的HM患者及粒细胞缺乏者为甚,应加强监控。

Investigation and analysis of infection in hospitalized patients with hematological malignancies

Objective To investigate the clinical characteristics of infection in patients with hematological malignancies(HM).Methods A retrospective review of the medical records of 327 HM patients with chemotherapy in 2004 were conducted.Results The infection rate was(33.64%),the main infection site was respiratory tract((40.85%));The isolation rate of gram-negative bacteria,gram-positive bacteria and fungi was(43.33%),(33.33%) and(23.34%) respectively.(70.58%) of infection occurred in patients with acute leukemia and all kinds of relapsed HM.The infection rate was(69.39%) and(18.64%) in agranulocytosis and non-agranulocytosis patients respectively(P<(0.05)).Conclusion Patients with HM were apt to develop infection,especially the patients with acute HM,all kinds of relapsed HM and agranulocytosis,so monitoring should be strengthened.