| 固态青霉素钾的降解动力学研究 |
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| 引用本文： | 赵强,詹先成,李琳丽,尹小东,何宁.固态青霉素钾的降解动力学研究[J].四川大学学报(医学版),2005,36(5):717-719. |
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| 作者姓名： | 赵强 詹先成 李琳丽 尹小东 何宁 |
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| 作者单位： | 电子科技大学生命科学与技术学院,成都,610054;四川大学华西药学院,物理化学教研室 |
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| 基金项目： | 国家自然科学基金(批准号30171117)资助 |
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| 摘 要： | 目的研究不同温度和相对湿度条件下青霉素钾降解的动力学规律。方法在恒温恒湿条件下使青霉素钾降解,定时测定其含量,并对获得的数据进行数学分析。结果青霉素钾的降解反应速率为-dc/dt=k(c0-c B),降解曲线符合c=c0-Bexp(kt) B,速率常数k可表达为k=Aexp(-Ea/RT)exp(mHr),其中活化能Ea=77.26kJ/mol,常数m=0.1159。结论反应速率表达式表述了青霉素钾的降解过程,符合其实际降解规律。
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| 关 键 词： | 青霉素钾 稳定性 温度 相对湿度 降解动力学 |
| 收稿时间： | 2004-11-26 |
| 修稿时间： | 2004年11月26 |
Kinetic Study on the Degradation of Penicillin Potassium at Different Temperature and Relative Humidity |
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| ZHAO Qiang,ZHAN Xian-Cheng,LI Lin-Li,YING Xiao-dong,HE Ning.Kinetic Study on the Degradation of Penicillin Potassium at Different Temperature and Relative Humidity[J].Journal of West China University of Medical Sciences,2005,36(5):717-719. |
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| Authors: | ZHAO Qiang ZHAN Xian-Cheng LI Lin-Li YING Xiao-dong HE Ning |
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| Institution: | Institute of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China. |
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| Abstract: | OBJECTIVE: To perform a kinetic analysis and formulation of the degradation of penicillin potassium in the solid phase at different temperature and relative humidity. METHODS: Penicillin potassium was incubated in a temperature-and-humidity-controlled oven at different temperature and relative humidity, and was determined by HPLC at suitable time intervals during the incubation. RESULTS: The reaction rate was expressed as -dc/dt=k(c0-c+B), where c is the residual concentration, k degradation rate constant, c0 original concentration and B a constant related to original concentration of degradant. Degradation curves were fitted with c=c0-Bexp (kt)+B. The k was expressed as k=Aexp(-Ea/RT)exp(mHr), where active energy E. is 77.26 kJ/mol and constant m 0.1159. CONCLUSION: The degradation of penicillin potassium could be expressed with c=c0-Bexp Aexp (-Ea/RT)exp (mHr)t]+B. |
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| Keywords: | Penicillin potassium Stability Temperature Relative humidity Degradation kinetics |
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