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冠心病患者血清E-选择素和Ox-LDL的测定及意义
引用本文:孙丽,郭晓玲.冠心病患者血清E-选择素和Ox-LDL的测定及意义[J].包头医学院学报,2008,24(6).
作者姓名:孙丽  郭晓玲
作者单位:包头医学院第一附属医院心内科,内蒙古,包头,014010;包头医学院第一附属医院心内科,内蒙古,包头,014010
摘    要:目的:测定血清可溶性E-选择素、氧化性低密度脂蛋白(Ox—LDL)浓度在冠心病患者以及健康人中的变化,探讨血清可溶性E-选择素、Ox—LDL浓度在冠心病患者中的意义以及二者之间在冠心病的发生、发展过程中的关系。方法:选择90例冠心病患者,将其分为急性心肌梗死组(AMI组)、不稳定性心绞痛组(UAP组)、稳定性心绞痛组(SAP组)各30例,正常对照组30例,采用酶联免疫吸附法检测各组血清可溶性E-选择素、Ox—LDL水平,用t检验比较各组间的差异,用直线相关分析二者之间是否具有相关性。结果:外周血中E-选择素和Ox—LDL的浓度在AMI组(67.84±11.08)ug/mL、(0.87±0.15)mg/L,UAP组(63.14±12.51)ug/mL、(0.78±0.16)mg/mL,SAP组(48.57±12.91)ug/mL、(0.65±0.22)mg/L,对照组(35.72±14.65)ug/mL、(0.51±0.21)mg/L;外周血中E-选择素和Ox—LDL的浓度在AMI组、UAP组、SAP组显著高于对照组(P〈0.01),外周血中E-选择素和Ox—LDL的浓度在AMI组、UAP组显著高于SAP组(P〈0.01),冠心病患者外周血中E-选择素与Ox—LDL具有明显相关性。结论:冠心病患者血清可溶性E-选择素水平和Ox—LDL水平可反映病情严重程度,对病情的发展具有预见性,可作为冠心病患者的辅。助诊断手段。

关 键 词:冠状动脉疾病  E-选择素  氧化性低密度脂蛋白

Determination of Soluble E-slectin and Ox-LDL in the Patients with Coronary Artery Disease
SUN Li,GUO Xiaoling.Determination of Soluble E-slectin and Ox-LDL in the Patients with Coronary Artery Disease[J].Journal of Baotou Medical College,2008,24(6).
Authors:SUN Li  GUO Xiaoling
Abstract:Objictive: To evaluate the role of soluble E-selectin and Ox-LDL in different coronary heart disease and the normal and to investigate the relationship of the both with the development of coronary heart disease.Methods: 90 cases of coronary heart disease were divided into the acute myocardial infarction group(30 cases),the unstable angina group(30 cases) and stable angina group(30 cases),with 30 normal controls.Serum level of solube E-selectin and Ox-LDL was measured by enzyme-linked immunosorbent assay.The...
Keywords:Coronary artery disease  E-selectin  Ox-LDL  
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