| 碱性成纤维细胞生长因子对鼠弥漫性轴索损伤治疗作用的实验研究 |
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| 引用本文： | 潘继明,崔新国.碱性成纤维细胞生长因子对鼠弥漫性轴索损伤治疗作用的实验研究[J].滨州医学院学报,2004,27(4):253-255. |
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| 作者姓名： | 潘继明 崔新国 |
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| 作者单位： | 烟台市烟台山医院,烟台市,264001;烟台市烟台山医院,烟台市,264001 |
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| 摘 要： | 目的:探讨碱性成纤维细胞生长因子(bFGF)对弥漫性轴索损伤的保护作用.方法:54只SD大鼠随机分为正常组、创伤组及创伤治疗组,对弥漫性轴索损伤的SD大鼠在伤后即刻腹腔注射bFGF,并于损伤后0、12、24、72、120 h分别测定创伤组及创伤治疗组脑白质SOD、MDA及Ca2 含量的变化,并与正常组进行比较.结果:与正常组相比,创伤组大鼠脑白质MDA、Ca2 含量明显上升,SOD含量明显下降(P＜0.05).而与创伤组相比,创伤治疗组脑白质MDA、Ca2 含量均降低,SOD含量则明显升高.结论:早期应用bFGF可以抑制脑白质内自由基的产生及Ca2 的超载,对弥漫性轴索损伤具有保护作用.
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| 关 键 词： | 碱性成纤维细胞生长因子 弥漫性轴索损伤 SOD MDA Ca2+ |
| 文章编号： | 1001-9510(2004)04-0253-03 |
| 修稿时间： | 2004年3月4日 |
THERAPEUTICAL EFFECT OF BASIC FIBROBLAST GROWTH FACTOR ON DIFFUSE AXONAL INJURY IN RATS |
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| PAN Jiming,CUI Xinguo.THERAPEUTICAL EFFECT OF BASIC FIBROBLAST GROWTH FACTOR ON DIFFUSE AXONAL INJURY IN RATS[J].Journal of Binzhou Medical College,2004,27(4):253-255. |
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| Authors: | PAN Jiming CUI Xinguo |
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| Abstract: | Objective:To investigate the neuroprotective effect of basic fibroblast growth factor(bFGF) on diffuse axonal injury(DAI).Methods:Fifty four Sprague Dawley rats were randomly divided into three groups,control,trauma and treatment.In the treatment group,bFGF was administered intraperitoneally immediately following diffuse axonal injury.The contents of SOD,MDA and Ca 2+ in white matter of brain were measured at 0,12,24,72 and 120 h after brain trauma.Results:Compared with those in control group,the contents of SOD decreased significantly in trauma group ( P <0 05).However,the contents of MDA and Ca 2+ in treatment group were significantly lower than those in trauma group( P <0 05).Conclusion:bFGF used in early stage can inhibit the increase of free radicals and the calcium overload in brain white matter and attenuate diffuse axonal injury. |
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| Keywords: | basic fibroblast growth factor diffuse axonal injury SOD MDA Ca 2+ |
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