| 龙血竭对组织工程皮肤修复皮肤缺损的作用 |
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| 引用本文： | 刘爱军,朱永红,赵钟祥,张立群,杜标炎,邝枣园,李彩霞,易华. 龙血竭对组织工程皮肤修复皮肤缺损的作用[J]. 广州中医药大学学报, 2009, 26(3) |
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| 作者姓名： | 刘爱军 朱永红 赵钟祥 张立群 杜标炎 邝枣园 李彩霞 易华 |
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| 作者单位： | 广州中医药大学基础医学院,广东广州,510006;中山大学中山医学院,广东广州,510080;广州中医药大学中药学院,广东广州,510006 |
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| 基金项目： | 广东省自然科学基金,广东省中医药管理局基金 |
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| 摘 要： | [目的]观察龙血竭对组织工程皮肤修复皮肤缺损创面的促进作用.[方法]将人成纤维细胞种植入胶原海绵,人角质形成细胞种植在表层,构建组织工程皮肤,并移植入裸鼠皮肤缺损创面;实验动物随机分为4组,选用活血圣药龙血竭于移植后2 d分别进行创面外敷、单纯口服、创面外敷+口服治疗,并设空白对照组.组织工程皮肤移植后9 d取材检测,观察创面局部表皮厚度、真皮层中层粘连蛋白(Ln)、Ⅰ型胶原蛋白的表达及毛细血管增生情况.[结果]龙血竭能促进组织工程皮肤移植后表皮的发育及真皮层中毛细血管的增生,增强Ln、Ⅰ型胶原蛋白的分泌,龙血竭外敷+口服组效果最佳.[结论]龙血竭对组织工程皮肤修复皮肤创面有促进作用.
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| 关 键 词： | 龙血竭/药理学 皮肤缺损/中西医结合疗法 皮肤移植 组织工程皮肤/病理学 细胞培养 |
Effect of Resina Draconis on the Repair of Skin Defect Treated with Tissue Engineering Skin |
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| LIU Aijun,ZHU Yonghong,ZHAO Zhongxiang,ZHANG Liqun,DU Biaoyan,KUANG Zaoyuan,LI Caixia,YI Hua. Effect of Resina Draconis on the Repair of Skin Defect Treated with Tissue Engineering Skin[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2009, 26(3) |
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| Authors: | LIU Aijun ZHU Yonghong ZHAO Zhongxiang ZHANG Liqun DU Biaoyan KUANG Zaoyuan LI Caixia YI Hua |
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| Affiliation: | 1.School of Basic Medical Science;Guangzhou University of TCM;Guangzhou 510006 Guangdong;China;2.Zhongshan School of Medicine;Sun Yat-sen University;Guangzhou 510080 Guangdong;3.School of Chinese Herbal Medicine;China |
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| Abstract: | Objective To investigate the effect of Resina Draconis(RD)on the repair of skin defect treated with tissue engineering skin.Methods The tissue engineering skin was constructed with collagen sponge as the dermal scaffolds where human skin fibroblasts were transplanted inside and human keratinocytes were transplanted on the surface.Then the tissue engineering skin was transplanted into the skin wounds in naked mice with skin defects.After transplatation for 2 days,RD was used for the treatment.According to th... |
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| Keywords: | RESINA DRACONIS/pharmacology SKIN DEFECT/TCM-WM therapy DERMAL TRANSPLANTATION TISSUE ENGINEERING SKIN/pathology CELL CULTURE |
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