Induction of plasminogen activator inhibitor type-1 (PAI-1) by hypoxia and irradiation in human head and neck carcinoma cell lines |
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| Authors: | Daniela Schilling Christine Bayer Anneke Geurts-Moespot Fred CGJ Sweep Martin Pruschy Karin Mengele Lisa D Sprague Michael Molls |
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| Affiliation: | 1.Department of Radiation Oncology, Klinikum rechts der Isar,Technical University of Munich,Munich,Germany;2.GSF – Institute of Pathology, KKG,Innate Immunity in Tumor Biology,Neuherberg,Germany;3.Department of Chemical Endocrinology,Radboud University Nijmegen Medical Centre,Nijmegen,The Netherlands;4.Department of Radiation Oncology,University Hospital Zürich,Zürich,Switzerland;5.Clinical Research Unit of the Department of Obstetrics and Gynaecology, Klinikum rechts der Isar,Technical University of Munich,München,Germany;6.Institute of Molecular Pathogenesis,Friedrich-Loeffler-Institut,Jena,Germany |
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| Abstract: | Background Squamous cell carcinoma of the head and neck (SCCHN) often contain highly radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality for these tumours. Reoxygenation during fractionated radiotherapy is desired to render these hypoxic tumour regions more radiosensitive. Hypoxia additionally leads to up-regulation of PAI-1, a protein involved in tumour progression and an established prognostic marker for poor outcome. However, the impact of reoxygenation and radiation on PAI-1 levels is not yet clear. Therefore, we investigated the kinetics of PAI-1 expression and secretion after hypoxia and reoxygenation, and determined the influence of ionizing radiation on PAI-1 levels in the two human SCCHN cell lines, BHY and FaDu. |
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