四川省抗菌药不良反应调查分析

目的:对四川省2002～2005年上报的抗菌药物不良反应(ADRs)进行统计分析。方法:采用回顾性研究的方法,对四川省2002～2005年上报的2668例抗菌药物ADRs进行系统分析。结果:发生ADRs以喹诺酮类最多(占30.13%)。给药途径以注射最高(占80.51%)。ADRs评价为"很可能"的最多(占58.73%)。ADRs的转归治愈1164例,好转1496例,有后遗症的5例,死亡3例。所有ADRs中皮肤及其附件损害占38.94%。结论:抗菌药物ADRs的发生与多种因素有关。临床上需进一步进行ADRs监测,以达到更合理、安全、有效地使用抗菌药物,减少ADRs的发生。

Analysis of ADRs Caused by Anti-bacteria Agents in Sichuan Province

Objective:To analyse the adveree drug reactions ADRs caused by anti-bacteria agents in Sichuan province from 2002 to 2005.Method:Restrospective research was used to analyse 2668 cases ADRs caused by anti-bacteria agents in Sichuan province from 2002 to 2005.Result:The top drug caused ADRs was quinolines(30.13%).The way of giving drugs used mostly was injection (80.51%).Most ADRs were evaluated as"probably"(58.73%).The prognosis of 1164 patients with ADRs were cured,1496 patients got better,5 cases had sequela and dead cases were 3.Skin and its appendix lesions accounted for 38.94% of all reported ADRs. Conclusion:The occurrence of ADRs caused by anti-bacteria agents are due to many factors.It must be further monitor clinically to decrease the happen of ADRs.