膳食锌缺乏对发育鼠脑内NOS活性及cGMP水平的影响

一氧化氮作为一种气体性的信使分子在神经系统中参与神经细胞间的信息传递，对脑发育、学习和记忆等具有重要作用。本文研究了膳食锌缺乏对发育鼠小脑，纹状体和下丘脑中的一氧化氮合成酶（ＮＯＳ）活性和ｃＧＭＰ水平的影响，结果表明：小脑、纹状体和下丘脑中的ＮＯＳ活性和ｃＧＭＰ水平均呈发育性增高的趋势。各年龄段锌缺乏鼠小脑、纹状体和下丘脑ＮＯＳ活性均显著低于正常对照组；２１和３０日龄缺锌组仔鼠小脑、纹状体和下丘脑中的ｃＧＭＰ水平明显低于自由喂养组，锌缺乏时ＮＭＤＡ受体－ＮＯ－ｃＧＭＰ通路受损可能是锌缺乏影响脑发育和功能的一个重要机制。

EFFECT OF DEETARY ZINC DEFICIENCY ON NOS ACTIVITY AND cGMP LEVEL OF CERTAIN REGIONS IN DEVELOPING RAT BRAIN

itric oxide,an gasous messenger molecule,involves in neurotransmiS-sion in CNS,and plays an important role in brain development and func-tions such as in learning and memory. The effect of dietary zinc deficiencyon NOS activity and cGMP Ievels of cerebellum,striatum and hypothalamusin developing rat brain were studied.The results showed that there were anontogenetic increase in NOS activity and cGMP Ievels.NOS activity of theseregions in ZD rats was significantly lower tlian that of AL group, and cGMPlevels in the above three regions in ZD rats of 21 and 30 davs of age werelower than that of AL group。Impaired NMDA receptor-NO-cGMP pathwayin zinc deficiency might be an important mechanism by which dietary zincdeficiency influenced brain development and functions。