| 盐酸丙哌维林片稳定性及溶出度研究 |
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| 引用本文： | 刘玉玲 王Zheng. 盐酸丙哌维林片稳定性及溶出度研究[J]. 中国药学杂志, 1997, 32(4): 229-231 |
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| 作者姓名： | 刘玉玲 王Zheng |
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| 作者单位： | 中国医学科学院中国协和医科大学药物研究所 |
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| 摘 要： | 目的:对盐酸丙哌维林片剂的稳定性和溶出度进行系统研究。方法:采用高效液相色语-紫外检测法为测定影响因素试验、加速试验及室温留样条件下的稳定性和溶出度。结果:在各种考察条件下，样品的外观、含量、有关物质及溶出度均未发生明显变化，45min时溶出度在85%以上。结论:盐酸丙哌维林片剂质量稳定，并具有较好的溶出性能。
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| 关 键 词： | 盐酸丙哌维林 高效液相色谱 稳定性 溶出度 |
| 收稿时间： | 1996-03-15; |
Stability and dissolution study of propiverine hydrochloride tablets |
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| Liu Yuling. Stability and dissolution study of propiverine hydrochloride tablets[J]. Chinese Pharmaceutical Journal, 1997, 32(4): 229-231 |
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| Authors: | Liu Yuling |
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| Affiliation: | ( Liu YL)，Wang Zheng( Wang Z)，Xia Xuejun(Xia XJ)，el a |
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| Abstract: | OBJECTIVE:To investigate the stability and dissolution of propiverine hydrochloride tablets systematically. METHODS: HPLC UV was used to determine the stability and dissolution of the samples to be laid in the condition of severe test, accelerated test and long term storage test. RESULTS:Outward appearance, content, related substance and dissolution of the samples were not changed, and the dissolution rate was more than 85% in 45 min. CONCLUSION:The results show that propiverine hydrochloride tablets have good stability and dissolution. |
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| Keywords: | propiverine hydrochloride HPLC stability dissolution |
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