| 基于化学计量学分析方法黄芪药材质量评价体系的建立 |
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| 引用本文： | 汪祺,郑笑为,刘燕,姚令文,戴忠,马双成.基于化学计量学分析方法黄芪药材质量评价体系的建立[J].中草药,2015,46(12):1825-1829. |
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| 作者姓名： | 汪祺 郑笑为 刘燕 姚令文 戴忠 马双成 |
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| 作者单位： | 中国食品药品检定研究院, 北京 100050;中国食品药品检定研究院, 北京 100050;中国食品药品检定研究院, 北京 100050;中国食品药品检定研究院, 北京 100050;中国食品药品检定研究院, 北京 100050;中国食品药品检定研究院, 北京 100050 |
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| 基金项目： | 国家重大新药创制(2009ZX09308-001) |
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| 摘 要： | 目的采用化学计量学分析方法,建立黄芪Astragalus membranaceus药材质量评价体系。方法收集20批不同产地不同品种黄芪药材,建立皂苷、黄酮类成分特征图谱。运用主成分分析、聚类分析方法深入研究不同黄芪药材中化学成分量的变化趋势及规律。结果 17个特征成分中,黄芪皂苷Ⅰ、黄芪皂苷ⅣV、芒柄花素和2个未知皂苷成分的差异显著,可作为区分不同产地或不同品种黄芪的关键性指标成分。结论通过化学计量学分析方法,建立的黄芪药材中皂苷、黄酮类成分评价体系专属性强、准确性高,可有效控制和评价黄芪药材质量。
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| 关 键 词： | 黄芪 特征图谱 化学计量学 质量评价体系 黄芪皂苷I 黄芪皂苷IV 芒柄花素 |
| 收稿时间： | 2015/1/19 0:00:00 |
Quality evaluation system of Astragali Radix by chemometrics |
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| WANG Qi,ZHENG Xiao-wei,LIU Yan,YAO Ling-wen,DAI Zhong and MA Shuang-cheng.Quality evaluation system of Astragali Radix by chemometrics[J].Chinese Traditional and Herbal Drugs,2015,46(12):1825-1829. |
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| Authors: | WANG Qi ZHENG Xiao-wei LIU Yan YAO Ling-wen DAI Zhong and MA Shuang-cheng |
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| Institution: | National Institute for Food and Drug Control, Beijing 100050, China;National Institute for Food and Drug Control, Beijing 100050, China;National Institute for Food and Drug Control, Beijing 100050, China;National Institute for Food and Drug Control, Beijing 100050, China;National Institute for Food and Drug Control, Beijing 100050, China;National Institute for Food and Drug Control, Beijing 100050, China |
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| Abstract: | Objective To form the evaluation system of Astragali Radix by chemometrics. Methods To establish the characteristic chromatogram for Astragali Radix with 20 samples from different regions and to analyze the methods data by principal components analysis and cluster analysis. Results There is significant difference in the content of astragaloside I, IV, formononetin, and z6, z7 (unknown components) among the 17 characteristic components. And these components can be the critical index to distinguish the origin. Conclusion It is a sensitivity evaluation system for the quality control of Astragali Radix. |
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| Keywords: | Astragali Radix characteristic spectrum chemometrics quality evaluation system astragaloside I astragaloside IV formononetin |
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