Synthesis and immunofluorescence assay of a new biotinylated paclitaxel |
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| Authors: | Sambaiah Thota King Ke Yung Tsay Shwu Chen Mei Nai Wen Hakimclahi Sharcon Lai Yiu Kay Lieu Chien Hui Hwu Jih Ru |
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| Affiliation: | Department of Chemistry, Organosilicon and Synthesis Laboratory, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC. |
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| Abstract: | 7-(5'-Biotinylamidopropanoyl)paclitaxel was synthesised by chemical methods; its immunofluorescence assay and the cell uptake experiments were performed by use of human leukemia U937 cells. The results indicate that paclitaxel is arresting cell cycle at the G(2)M phase only. |
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