Chronic stress enhances apomorphine-induced stereotyped behavior in mice: Involvement of endogenous opioids |
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| Authors: | Simona Cabib Stefano Puglisi-Allegra Alberto Oliverio |
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| Affiliation: | 2. Istituto di Psicobiologia e Psicofarmacologia, C.N.R., Italy;1. Department of Genetics and Molecular Biology, Università di Roma, Roma (Italy) |
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| Abstract: | Mice subjected to repeated stressful experiences showed an increase in stereotypic climbing behavior induced by apomorphine thus suggesting a modified sensitivity of dopaminergic receptors. Naltrexone, injected before each stressful experience, reversed this effect of chronic stress indicating an involvement of endogenous opioids. |
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| Keywords: | chronic stress endogenous opioids apomorphine climbing behavior mouse |
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