川芎嗪治疗大鼠缺血皮瓣的实验研究

目的:研究中药提取物川芎嗪对超长随意皮瓣存活的影响,探讨中药治疗缺血皮瓣的可能性及疗效。方法:实验大鼠分为四组,构筑经典的大鼠“McFarlane flap”模型;空白对照组每只每天腹腔注射生理盐水1ml/kg;低剂量组每只每天腹腔注射盐酸川芎嗪15mg/kg;中剂量组每只每天腹腔注射盐酸川芎嗪150mg/kg;高剂量组每只每天腹腔注射盐酸川芎嗪225mg/kg;测定皮瓣成活面积及百分率,观察川芎嗪对缺血皮瓣成活的影响。结果:皮瓣成活率,中剂量组显著高于对照组(P<0.05),低剂量组和高剂量组皮瓣成活率和对照组比较差异无显著性意义(P>0.05)。结论:全身适当剂量使用川芎嗪治疗可提高局部缺血皮瓣的成活率。

Study of Tetramethylpyrazine on Treating Ischemic Skin Flap

Objective:To explore the effect of tetramethylpyrazine on treating ischemic skin flap and discuss the possibility and curative effect of TCM on treating ischemic skin flap. Methods:Experimental rats were divided into four groups and the "McFarlane flap" rat models were established. The contrast group was celiac injected by 1ml NS each day. The small dose group, the middle dose group and the high dose group were celiac injected by 15mg/kg, 150mg/kg and 225mg/kg tetramethylpyrazine each day respectively. The viable area ratio of skin flap was measured and the effect of tetramethylpyrazine on the viable ischemic skin flap observed. Results:The viable ratio of skin flap in the middle dose group was obviously higher than that in the contrast group (P<0.05). The viable ratio of skin flap in the smafl dose group and the high dose group had no significant difference from that in the contrast group (P<0.05). Conclusion:Tetramethylpyrazine with the middle dose can improve the viable ratio of local ischemic skin flap.