| 基于化学成分和药理效应的荆芥传统分段加工与一体化加工工艺比较 |
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| 引用本文： | 钱岩,于生,单鸣秋,姚卫峰,张丽.基于化学成分和药理效应的荆芥传统分段加工与一体化加工工艺比较[J].中国中药杂志,2016,41(11):2081-2086. |
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| 作者姓名： | 钱岩 于生 单鸣秋 姚卫峰 张丽 |
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| 作者单位： | 南京中医药大学 江苏省中药资源产业化过程协同创新中心/中药资源产业化与 方剂创新药物国家地方联合工程研究中心, 江苏 南京210023,南京中医药大学 江苏省中药资源产业化过程协同创新中心/中药资源产业化与 方剂创新药物国家地方联合工程研究中心, 江苏 南京210023,南京中医药大学 江苏省中药资源产业化过程协同创新中心/中药资源产业化与 方剂创新药物国家地方联合工程研究中心, 江苏 南京210023,南京中医药大学 江苏省中药资源产业化过程协同创新中心/中药资源产业化与 方剂创新药物国家地方联合工程研究中心, 江苏 南京210023,南京中医药大学 江苏省中药资源产业化过程协同创新中心/中药资源产业化与 方剂创新药物国家地方联合工程研究中心, 江苏 南京210023 |
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| 基金项目： | 国家自然科学基金面上项目(81473313);江苏省中药资源产业化过程协同创新中心项目(ZDXM-1-3);江苏省高校自然科学研究面上项目(15KJB360010,14KJD360001);科技基础性工作专项(2014FY111100-11);江苏高校优势学科建设工程项目(ysxk-2014);江苏高校品牌专业建设工程项目(PPZY2015A070) |
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| 摘 要： | 测定荆芥经饮片一体化加工与传统分段加工后所得产品中挥发油的含量,并采用GC-MS测定挥发油中8个代表性化合物(薄荷酮、胡薄荷酮、1-辛烯-3-酮、d-柠檬烯、β-石竹烯、β-香叶烯、薄荷呋喃、3-辛酮)的含量,通过二甲苯致小鼠耳廓肿胀模型,考察荆芥2种加工方法抗炎作用的差异。通过对荆芥不同加工产品挥发性成分含量与功效的比较,阐述荆芥药材、饮片一体化加工工艺的合理性。结果显示,荆芥一体化工艺加工产品8个化合物含量均高于传统工艺产品;2种加工方法均能降低小鼠耳廓肿胀度、降低致炎小鼠血清中TNF-α,IL-1β和IL-6的含量,产生抗炎作用。经过同剂量间比较,一体化加工工艺的抗炎作用整体上优于传统加工工艺。相比传统分段加工工艺,一体化加工在保证饮片质量的同时,提高了效率、节约时间及人工成本,具有合理性。
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| 关 键 词： | 荆芥 一体化 化学成分 抗炎 |
| 收稿时间： | 4/1/2016 12:00:00 AM |
Comparison between traditional processing and integration processing for Schizonepetae Herba based on chemical constituents and pharmacological effect |
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| QIAN Yan,YU Sheng,SHAN Ming-qiu,YAO Wei-feng and ZHANG Li.Comparison between traditional processing and integration processing for Schizonepetae Herba based on chemical constituents and pharmacological effect[J].China Journal of Chinese Materia Medica,2016,41(11):2081-2086. |
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| Authors: | QIAN Yan YU Sheng SHAN Ming-qiu YAO Wei-feng and ZHANG Li |
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| Institution: | Jiangsu Provincial Collaborative Innovation Center of Traditional Chinese Medicinal Resource Industrialization/National and Local Collaborative Engineering Center of Traditional Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Provincial Collaborative Innovation Center of Traditional Chinese Medicinal Resource Industrialization/National and Local Collaborative Engineering Center of Traditional Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Provincial Collaborative Innovation Center of Traditional Chinese Medicinal Resource Industrialization/National and Local Collaborative Engineering Center of Traditional Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Provincial Collaborative Innovation Center of Traditional Chinese Medicinal Resource Industrialization/National and Local Collaborative Engineering Center of Traditional Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China and Jiangsu Provincial Collaborative Innovation Center of Traditional Chinese Medicinal Resource Industrialization/National and Local Collaborative Engineering Center of Traditional Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China |
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| Abstract: | |
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| Keywords: | Schizonepetae Herba integration chemical component anti-inflammatory |
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