| 光果翠雀止血作用机制研究及安全性评价 |
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| 引用本文： | 费改顺,贾正平,盛杰.光果翠雀止血作用机制研究及安全性评价[J].中国药业,2014(16):37-39. |
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| 作者姓名： | 费改顺 贾正平 盛杰 |
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| 作者单位： | 中国人民解放军兰州军区兰州总医院,甘肃兰州730050 |
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| 基金项目： | 军队“十一五”医药重大专项课题（用于创伤止血镇痛的军队特需“创愈散”的研究）,项目编号：06D005-4. |
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| 摘 要： | 目的 研究光果翠雀的止血作用机制及安全性。方法 观察光果翠雀大鼠灌胃给药对凝血酶原时间（PT）,部分凝血活酶活性时间（APTT）、凝血酶时间（TT）及纤维蛋白原含量（FIB）的影响。采用大白兔破损皮肤外用试验观察光果翠雀的皮肤刺激性及皮肤吸收毒性,采用小鼠口服观察光果翠雀口服的急性毒性。结果 小鼠口服光果翠雀能显著缩PT和APTT;光果翠雀破损皮肤外用未见明显的皮肤刺激性和吸收毒性,但口服毒性显著。结论 光果翠雀能明显缩短PT及APTT,外用安全,但口服具有显著的毒性。
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| 关 键 词： | 光果翠雀 止血机制 安全性 |
Study on Hemostasis Mechanism and Safety Evaluation of Delphinium Grandiflorum L. var. Leiocarpum |
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| Fei Gaishun,Jia Zhengping,Sheng Jie.Study on Hemostasis Mechanism and Safety Evaluation of Delphinium Grandiflorum L. var. Leiocarpum[J].China Pharmaceuticals,2014(16):37-39. |
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| Authors: | Fei Gaishun Jia Zhengping Sheng Jie |
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| Institution: | (Lanzhou General Hospital, Lanzhou Command, Lanzhou, Gansu, China 7300.50) |
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| Abstract: | Objective To investigate the hemostasis mechanism and safety of delphinium grandiflorum L var. leioearpum（DGVL）. Methods The effects of intragastric administration of DGVL on prothrombin time（PT）,activated partial thromboplastin time （APTY）,thrombin time （TT） and fibrinogen concentration（FIB） in rat arterial blood were observed. The toxicity of DGVL absorbed by damaged rabbit skin and the acute toxicity in mice by oral administration were evaluated respectively. Results DGVL could shorten PT and APTT in rat arterial blood remarkably, and had no obvious effect on TT and FIB. The skin stimulation and the absorption toxicity were not shown in rabbit. Conclusion DGVL could shorten PT and APTT in rat arterial blood remarkably,its external use is safe.but its oral administration has significant toxicity. |
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| Keywords: | delphinium grandiflorum L var leiocarpum hemostasis mechanism safety |
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