帕罗西汀联合喹硫平治疗抑郁症的疗效观察

目的观察帕罗西汀联合喹硫平治疗抑郁症的疗效和安全性。方法将55例在精神病专科医院接受住院治疗的抑郁症患者随机分配为两组，疗程为4周。用汉密尔顿抑郁量表（HRSD）进行疗效评定，用副反应量表（TESS）评估患者的药品不良反应，采用重复测量的方差分析比较帕罗西汀联合喹硫平与单用帕罗西丁治疗抑郁症的起效快慢及疗效。结果在4周的疗程中，分组与时间之间存在交互作用（F=7．107，P=0．000），两组药品不良反应之间无统计学差异（r=0．162，P=0．688〉0．05）。两组在第4周末的疗效有统计学差异（t=5．720，P=0．000〈0．05）。结论帕罗西汀合用喹硫平治疗抑郁症起效时间及疗效均优于单用帕罗西汀，联合用药未增加药物的不良反应。

Efficacy of Paroxetine Combined with Quetiapine in Treating Depressive Disorder

Objective To observe the efficacy and safety of paroxetine combined with quetiapine in treating depressive disorder. Methods 55 inpatients with depressive disorder in the psychiatric specialist hospital were randomly divided into 2 groups. The course of treatment was 4 weeks. The effects were evaluated by the Hamilton Rating Scale for Depression （HRSD） and the adverse reactions were evaluated by the Treatment Emergent Symptom Scale （TESS）. The repeated measures analysis of variance （ANOVA） was adopted to compare the initial effect time and effects between paroxetine combined with quetiapine and single paroxetine in treating depressive disorder. Results Throughout the 4-week treatment course,the interactions existed between group and time（F=7. 107 P =0. 000）,while no statistically difference existed among adverse reactions（Х^2=0. 162 P=0.688 〉 0.05）.The efficacy at the end of 4 weeks had statistical difference between the two groups（t=5.720 P=0. 000 〈 0.05）.Conclusion The initial effect time and effect of paroxetine combined with quetiapine in treating depressive disorder are superior to single use of paroxetine. The combination medication does not increase the adverse drug reactions.