复方汉防己颗粒治疗肝硬化160例

目的 观察复方汉防己颗粒治疗肝硬化的临床疗效并探讨其机理。方法 选择确诊的肝硬化患者320例,随机分为观察组与对照组,各160例。对照组采用常规肝硬化治疗,观察组给予患者服用复方汉防己颗粒,疗程均为1个月。观察临床疗效,检测患者治疗前后白蛋白含量、总胆红素含量、门静脉内径、丙氨酸氨基转移酶含量。结果 观察组患者治疗有效率为86.26%,明显高于对照组的59.38%（P〈0.05）。治疗后观察组白蛋白含量（32±5）g/L,明显高于对照组的（29±4）g/L;观察组总胆红素含量为（20.3±11.7）μmol/L,显著低于对照组的（23.2±10.5）μmol/L;观察组门静脉内径为（1.1±0.3）cm,明显短于对照组的（1.3±0.2）cm;观察组丙氨酸氨基转移酶含量为（0.83±0.23）μmol/L,显著低于对照组的（0.93±0.22）μmol/L（P〈0.05）。结论 与常用的保肝治疗方法相比,复方汉防己颗粒治疗肝硬化具有较高的治疗有效率,症状改善明显,用药方式简单,价格适宜。

Study on Role of Compound Hanfangji Granules for Treating Liver Cirrhosis in 160 Cases

Objective To observe the clinical effect of Compound Hanfangji Granules in the treatment of liver cirrhosis,and to explore its mechanism to provide the reference for clinic. Methods 320 cases of liver cirrhosis were selected and randomly divided into the observation group （160 cases） and the control group （160 cases）.The control group was treated by the routine treatment of liver cirrhosis,while the observation group was given Compound Hanfangji Granules. The treatment course in the two groups was 1 month. The clinical effects after treatment were observed. Albumin,total bilirubin,portal vein diameter,alanine aminotransferase were detected and the differences were compared between before and after treatment. Results The effective rate of the observation group was 86. 26% ,which was significantly higher than 59.38% in the control group,the difference was statistically significant （P 〈 0. 05）. The albumin content after treatment in the observation group was （32 ±5）g/L,which was significantly higher than（29±4 ）g/L in the control group;the total bilirubin content in the observation group was （20.3 ±11.7）μmol/L,which was significantly lower than（ 23.2±10.5）μmol/L in the control group;the portal vein diameter in observation group was （1. 1±0 3）cm,which was significantly shorter than （1.3 ±0.2）cm in the control group;the GPT content in the observation group was （0.83 ±0. 23）μmol/L,which was significantly lower than（0.93 ± 0. 22）μmol/L in the control group, the above differences were statistically significant （P 〈 0.05）. Conclusion Compared with usual liver-protective therapy,clinical use of Compound Hanfangji Granules has higher effective rate in the treatment of liver cirrhosis,obviously improves the symptoms with simple administration mode and proper price.