舒筋接骨丸对长管状骨骨折患者形态发生蛋白-7和血清瘦素的影响

目的探讨舒筋接骨丸对长管状骨骨折患者的临床疗效及安全性，并分析其对形态发生蛋白（BMP-7）和血清瘦素（LEP）的影响。方法将196例长管状骨骨折患者随机分为治疗组和对照组，各98例。两组均给予手法复位及内固定，对照组予以术后常规护理，治疗组加用舒筋接骨丸治疗，两组均连续治疗2周，比较患者治疗后的临床疗效、BMP-7和LEP的含量。结果治疗组总有效率为91．84％，明显高于对照组的71．43％，血清中BMP-7和LEP的含量均显著高于对照组（P〈0．01）；两组患者均未出现明显不良反应。结论舒筋接骨丸对长管状骨骨折有较好疗效，不良反应少，且能有效提高BMP-7和LEP的含量，加快骨折愈合，值得临床推广。

Influence of Shujinjiegu Pills on Bone Morphogenetic Protein -7 and Leptin in Patients with Long Tubular Bone Fracture

Objective To investigate the clinical effect and safety of Shujinjiegu Pills in treating long tubular bone fracture and to analyze its influence on the bone morphogenetic protein-7 （BMP-7） and leptin（LEP）. Methods 196 patients with long tubular bone fracture were randomly divided into the treatment group and the control group 198 cases in each group. Both groups were given the manipulative reduction and the internal fixation. After surgery,the control group was given the routine postoperative care and the treatment group was given Shujinjiegu Pills additionally. And both groups were treated for continuous 2 weeks. The clinical effects,BMP-7 and LEP contents after treatment were compared between the two groups. Results The total effective rate after treatment in the treatment group was 91.84% ,which was significantly higher than 71.43% in the control group;the serum contents of BMP-7 and LEP in the treatment group were significantly higher than those in the control group（ P 〈 0. 01 ）. No obvious adverse reactions occurred during treatment in the two groups. Conclusion Shujinjiegu Pills in treating long tubular bone fracture has better effect and few adverse reactions,can effectively improve the content of BMP- 7 and LEP,accelerate fracture healing,which is worthy of clinical promotion.