Ondansetron compared with metoclopramide in the treatment of established postoperative nausea and vomiting |
| |
Authors: | Diemunsch P; Conseiller C; Clyti N; Mamet JP and The French Ondansetron Study Group |
| |
Institution: | Hopital Civil, 67091 Strasbourg Cedex, France; Hopital Cochin, 75014 Paris Cedex, France; Laboratoire Glaxo Wellcome, 75016 Paris Cedex, France |
| |
Abstract: | We have studied 746 males and females undergoing general anaesthesia for
any type of surgical procedure in a double-blind, controlled, randomized
study. After experiencing at least one nausea and/or one emetic episode in
the 6 h after recovery from anaesthesia, patients received either
ondansetron 4 mg i.v. or metoclopramide 10 mg i.v. Patients were observed
for postoperative nausea and vomiting (PONV) for 24 h after drug
administration. Complete control of PONV was achieved more frequently in
the ondansetron-treated patients compared with the metoclopramide-treated
patients during the 24-h period (59% vs 41% (P < 0.001) and 44% vs 34%
(P = 0.006) for emetic episodes and nausea, respectively). Furthermore,
ondansetron was associated with greater patient satisfaction than
metoclopramide (P < 0.001) with 49% and 32% of patients, respectively,
very satisfied. The overall incidence of adverse events was similar in the
ondansetron (7%) and metoclopramide (8%) groups. Ondansetron was as well
tolerated and more effective than metoclopramide for all assessment
criteria in the treatment of established PONV.
|
| |
Keywords: | |
本文献已被 Oxford 等数据库收录! |
|