ASSESSMENT OF MOTOR ACTIVITY IN REGULATORY NEUROTOXICITY STUDIES: VALIDATION OF THE ETHOVISION VIDEO TRACKING SYSTEM IN RATS TREATED WITH AMPHETAMINE AND CHLORPROMAZINE |
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| Authors: | Guy Healing Philip W. Harvey Mary McFarlane Nicholas A.P.S. Buss Brian A. Mallyon Andrew Cockburn |
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| Affiliation: | Astra Charnwood Safety Assesment , Loughborough , Leicestershire , United Kingdom |
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| Abstract: | A novel automated computer imaging technique for assessing motor activity in rats to a standard acceptable for regulatory neurotoxicity studies is described. The Ethovision video tracking, motion analysis, and behavior recognition system is shown to reliably assess both increases and decreases in motor activity of rats treated with D-amphetamine sulfate or chlorpromazine hydrochloride, respectively, by demonstrating statistically significant treatment-related effects with each drug. It also has advantages over existing beam-breaking systems in ease of use and flexibility, and provides a permanent record on video tape of the subjects examined. |
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| Keywords: | Amphetamine Chlorpromazine Ethovision Video Tracking Motor Activity Neurotoxicity Rat |
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